| 上皮性卵巢癌组织RRM1和RRM2表达及其意义 |
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| 引用本文： | 卢飞飞,任婧婧,王黎明,孙显璐.上皮性卵巢癌组织RRM1和RRM2表达及其意义[J].齐鲁医学杂志,2011,26(5). |
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| 作者姓名： | 卢飞飞 任婧婧 王黎明 孙显璐 |
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| 作者单位： | 青岛大学医学院附属医院妇科,山东青岛,266003 |
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| 摘 要： | 目的 探讨核苷酸还原酶亚单位M1(RRM1)及M2(RRM2)在上皮性卵巢癌组织表达及意义.方法 采用免疫组化PV-6000二步法,分别检测15例正常卵巢组织、15例良性卵巢肿瘤组织和46例上皮性卵巢癌组织中RRM1和RRM2蛋白的表达,并分析RRM1和RRM2表达之间的关系.结果 上皮性卵巢癌组织RRM1蛋白表达阳性率为58.70%,高于正常卵巢组织(0)和良性卵巢肿瘤组织(26.67%),差异均有显著意义(x2=15.80、4.64,P＜0.05).上皮性卵巢癌组织RRM2蛋白表达阳性率为67.39%,高于正常卵巢组织(0)和良性卵巢肿瘤组织(20.00%),差异均有显著性(x2=15.80、10.30,P＜0.05).RRM1蛋白在上皮性卵巢癌低分化组表达阳性率(66.67%)高于高中分化组(30.00%),RRM2蛋白在FIGOⅢ～Ⅳ期上皮性卵巢癌表达阳性率(77.42%)高于Ⅰ～Ⅱ期(46.67%),差异均有显著性(x2=4.340、4.350,P＜0.05).上皮性卵巢癌组织RRM1和RRM2表达无相关性(r=0.264,P＞0.05).结论 RRM1和RRM2在上皮性卵巢癌组织表达上调,有望成为新的卵巢肿瘤分子标记物,两者在上皮性卵巢癌的发生发展过程中可能起到不同的作用.
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| 关 键 词： | 核苷酸还原酶类 卵巢肿瘤 免疫组织化学 |
EXPRESSIONS OF RRM1 AND RRM2 IN EPITHELIAN OVARIAN CANCER AND THEIR SIGNIFICANCE |
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| LU FEI-FEI,REN JING-JING,WANG LI-MING,SUN XIAN-LU.EXPRESSIONS OF RRM1 AND RRM2 IN EPITHELIAN OVARIAN CANCER AND THEIR SIGNIFICANCE[J].Medical Journal of Qilu,2011,26(5). |
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| Authors: | LU FEI-FEI REN JING-JING WANG LI-MING SUN XIAN-LU |
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| Institution: | LU FEI-FEI,REN JING-JING,WANG LI-MING,SUN XIAN-LU (Department of Obstetrics and Gynecology,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China) |
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| Abstract: | ObjectiveTo investigate the expressions of ribonucleotide reductase subunit M1 and M2(RRM1 and RRM2) in epithelial ovarian cancer(EOC) and their significance.MethodsThe expressions of RRM1 and RRM2 were detected by immunohistochemistry PV-6000 in formalin-fixed,paraffin-embedded specimens of 76 ovarian specimens(including 15 normal,15 benign and 46 malignant).The relationship between the expressions of two genes was analyzed.ResultsThe positive rates of RRM1 in ovarian cancer,normal and benign groups were 5... |
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| Keywords: | ribonucleotide reductases ovarian neoplasms immunohistochemistry |
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