| 氮酮促进复方替硝唑凝胶经皮渗透作用研究 |
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| 引用本文： | 张永军,于志庚,胡志林.氮酮促进复方替硝唑凝胶经皮渗透作用研究[J].中国药房,2004,15(9):537-538. |
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| 作者姓名： | 张永军 于志庚 胡志林 |
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| 作者单位： | 新疆石河子大学医学院附属第一医院,石河子市,832008 |
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| 摘 要： | 目的 :研究不同浓度的氮酮对复方替硝唑凝胶透皮吸收的作用 ,并筛选出最佳浓度。方法 :采用垂直式Franz扩散池 ,以不同浓度的氮酮作为促渗剂 ,应用反相高效液相色谱法测定处方中替硝唑、氯霉素、水杨酸3组分的含量并计算其单位面积累积透皮量。结果与结论 :不同浓度的氮酮对复方替硝唑凝胶中3组分的渗透性均有促进作用 ,其中浓度为2 %的氮酮透皮促渗作用最显著。
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| 关 键 词： | 复方替硝唑凝胶 氮酮 透皮吸收 反相高效液相色谱法 |
| 文章编号： | 1001-0408(2004)09-0537-02 |
| 修稿时间： | 2004年4月12日 |
Study of Azone in Percutaneous Permeation of Compound Tinidazole Gel |
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| ZHANG Yongjun,YU Zhigeng,HU Zhilin.Study of Azone in Percutaneous Permeation of Compound Tinidazole Gel[J].China Pharmacy,2004,15(9):537-538. |
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| Authors: | ZHANG Yongjun YU Zhigeng HU Zhilin |
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| Abstract: | OBJECTIVE:To study the enhancing effects of azone at different concentrations on percutaneous permeation of compound tinidazole gel and to find out the best concentration.METHODS:Using vertical Franz-type diffusion cell and difˉferent concentrations of azone as enhancer,the concentrations of tinidazole,chloramphenicol and salicylic acid in permeation solution were measured by RP-HPLC,then cumulative permeation quantity(Q)was calculated.RESULTS&CONCLUSION:Azone at different concentrations could promote the permeability of3ingredients of compound tinidazole gel,and2%azone had the most obvious permeation-enhancing effect. |
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| Keywords: | compound tinidazole gel azone percutaneous absorption RP-HPLC |
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