Cortical control of presynaptic inhibition of Ia afferents in humans |
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Authors: | S Meunier E Pierrot-Deseilligny |
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Institution: | Laboratoire de Neurophysiologie Clinique, Rééducation, H?pital de la Salpétrière, 47 boulevard de l’H?pital, F-75651 Paris cedex 13, France Fax: +33-142161102, FR
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Abstract: | The effect of transcranial magnetic stimulation was investigated on presynaptic inhibition of Ia terminals in the human upper
and lower limb. Presynaptic inhibition of Ia afferents was assessed by three different and independent methods: (1) heteronymous
Ia facilitation of the H-reflex (assessing ongoing presynaptic inhibition of Ia afferents in the conditioning volley); (2)
long-lasting inhibition of the H-reflex by a group I volley (D1 inhibition, assessing presynaptic inhibition on Ia afferents
in the test volley); (3) measurement of the monosynaptic Ia peak evoked in single motor units by a homonymous or heteronymous
volley (post stimulus time histogram method). The first two methods were used on the lower limb; the last two on the upper
limb. Provided that the corticospinal volley and the explored Ia volley were directed to the same target motoneurones, cortical
stimulation evoked significant and congruent changes: (1) In the lower limb, transcranial stimulation provided increased heteronymous
Ia facilitation and decreased D1 inhibition, both of which suggest a decrease in presynaptic inhibition of Ia afferents; (2) in the upper limb, transcranial stimulation provided an increase in the radial-induced
inhibition of the wrist flexor H-reflex and a decrease in the peak of monosynaptic Ia excitation in single units, both of
which suggest an increase in presynaptic inhibition. Selectivity of corticospinal effects was explored by testing presynaptic inhibition of Ia afferents
to soleus motoneurones and focusing the transcranial stimulation to excite preferentially different motor nuclei (soleus,
quadriceps and tibialis anterior). A cortical-induced decrease in presynaptic inhibition of Ia afferents was seen when, and
only when, cortical and peripheral Ia volleys were directed to the same motor nucleus.
Received: 18 July 1997 / Accepted: 10 November 1997 |
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Keywords: | Cortical stimulation Ia afferents Presynaptic inhibition Spinal interneurones Human |
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