Primary immune surveillance: some like it hot |
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Authors: | Joseph J Skitzki Qing Chen W C Wang Sharon S Evans |
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Institution: | (1) Department of Immunology, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY 14263, USA |
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Abstract: | The thermal element of fever has been found to be beneficial in models of infectious disease. The contributions of fever-range
temperatures to the efficacy of the adaptive immune response have only begun to be delineated. There is accumulating evidence
that fever-range thermal stress bolsters primary immune surveillance of lymph nodes and Peyer patches by augmenting lymphocyte
extravasation across specialized vessels termed high endothelial venules. Molecular mechanisms have recently come to light
by which the thermal component of fever alone may promote lymphocyte trafficking, and thereby the probability of mounting
a defense against microbial infection. Acquired knowledge of the molecular changes associated with thermal stress may allow
for the development of novel therapies for a variety of disease processes.
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Keywords: | Hyperthermia Lymphocyte trafficking Primary immune surveillance IL-6 |
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