| 应用SPECT和~(99m)Tc-ECD定量测定CBF和rCBF数学模型的设计 |
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| 引用本文： | 贾少微!,潘中允!.应用SPECT和~(99m)Tc-ECD定量测定CBF和rCBF数学模型的设计[J].中华物理医学杂志,1996(3). |
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| 作者姓名： | 贾少微! 潘中允! |
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| 作者单位： | 深圳市人民医院 |
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| 摘 要： | 在大量实验的基础上,根据Fick原理,设计了适合用SPECT和脑灌注显像剂~99mTc-ECD定量测定全脑血流量(CBF)和局部脑血流量(rCBF)的两种数学模型。在采血法数学模型中主要修正了脑平衡时间,改进了N值测定法;在非采血数学模型中采用头颈部平面像,由颈总动脉影像求得动脉血中~99mTc-ECD的浓度;提出SPECT断层像和平面像之间计数率的比例关系。用两种数学模型测得CBF和rCBF近似文献值。
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| 关 键 词： | 单光子发射计算机断层 脑血流量 数学模型 定量测定 |
Design of Mathematical Model for Quantifying Cerebral Blood Flow and Regional Cerebral Flow by SPEECT and "Tc-ECD |
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| Jia Shaowei,Pan Zhongyun. Shenzhen People's Hospital.Design of Mathematical Model for Quantifying Cerebral Blood Flow and Regional Cerebral Flow by SPEECT and "Tc-ECD[J].Chinese Journal of Physical Medicine and Rehabilitation,1996(3). |
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| Authors: | Jia Shaowei Pan Zhongyun Shenzhen People's Hospital |
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| Institution: | Jia Shaowei,Pan Zhongyun. Shenzhen People's Hospital,518020 |
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| Abstract: | Based on the Fick principle and lots of experiments mathematical models were deviaed for quantifying cerebral flow (DBF) and regional cerebral blood flow (rCBF) by SPECT and perfusion agent 99m Tc-ECD. The balance time of brain was revised and N value measarement of 99mTc-ECD was improved in mathematical of model of sampling blood. A cephalo-cervical planar image was used to measure concetration of 99mTc-ECD in arteral blood by common carotid atery, and the proportional relationship between SPECT transverse and planar images were decided in mathematical model of non-sampling blood. CBF and rCBF value quantified with both mathematical models were similar to referenaces. |
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| Keywords: | SPECT CBF and rCBF mathematical model quantitative |
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