三叉神经痛患者部分促炎因子水平变化及意义 |
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引用本文: | 黄姗姗,徐文华,马腾飞,肖芳莉,刘衍钊,王烈成,王元银.三叉神经痛患者部分促炎因子水平变化及意义[J].安徽医科大学学报,2015(5). |
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作者姓名: | 黄姗姗 徐文华 马腾飞 肖芳莉 刘衍钊 王烈成 王元银 |
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作者单位: | 安徽医科大学口腔医学院 安徽医科大学附属口腔医院 安徽省口腔疾病研究中心实验室,合肥,230032;安徽医科大学基础医学院生理学教研室,合肥,230032 |
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基金项目: | 国家自然科学基金,安徽省自然科学基金,安徽省高等学校省级优秀青年人才基金 |
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摘 要: | 收集30例三叉神经痛(TN)患者、17例恶性肿瘤患者、17例普通炎症患者及20例健康患者空腹静脉血,ELISA法检测血清中白介素-1β(IL-1β)、白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)的表达水平。 TN 组患者血清中 IL-1β、IL-6、TNF-α的表达水平均高于健康对照组,差异有统计学意义(P <0.05);而与恶性肿瘤组和普通炎症组比较,差异无统计学意义。 IL-1β、IL-6、TNF-α炎症因子与 TN 发病有一定关联。
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关 键 词: | 三叉神经痛 白介素-1β 白介素-6 肿瘤坏死因子-α 酶联免疫吸附试验 |
Variation of some inflammatory cytokines in patients with trigeminal neuralgia and its significance |
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Abstract: | Fasting venous blood of 30 trigeminal neuralgia (TN) patients, 17 cancer patients, 17 patients with general inflammation and 20 healthy people were enrolled in this study. The levels of IL-1β, IL-6 and TNF-α in se-rum were detected by ELISA. The serum levels of IL-1β, IL-6 and TNF-α in the TN group were significantly higher than those in the healthy group (P < 0. 05); however there were no significant differences with the cancer and in-flammatory patients group. The cytokines IL-1β, IL-6 and TNF-α are related with the pathogenesis of TN. |
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Keywords: | trigeminal neuralgia interleukin-1β interleukin-6 tumor necrosis factor-α ELISA |
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