Ⅰ期高血压对老年人认知功能影响的研究

目的：探讨Ⅰ期老年高血压患者认知功能的改变。方法用蒙特利尔认知量表( MoCA)评估老年高血压患者的认知功能。运用注意网络测试( ANT)评估Ⅰ期高血压患者3个注意网络(警觉、定向、执行控制)的效率。结果高血压组与正常血压组相比,MoCA视空间执行能力、注意力、延迟回忆和总得分均明显降低,差异有统计学意义(P <0．05)。高血压组在警觉和执行网络效率方面明显受损( P<0．05),而在定向网络、平均反应时间和正确率方面与正常血压组相比差异无统计学意义。结论未治疗的Ⅰ期老年高血压患者MoCA视空间执行能力、注意力、延迟回忆和总得分均明显降低,提示高血压患者存在认知功能损害。高血压患者注意网络出现明显损害,特别是在警觉和执行控制网络方面。

Effect of stage 1 essential hypertension on cognition in elderly patients

Objective The experiment is designed to investigate whether elderly patients of stage 1 essential hyper-tension had cognitive dysfunction. Methods Montreal Cognitive Assessment( MoCA) scale was used to investigate the cognitive function of the patients. The attention network test ( ANT) was used to investigate whether elderly hy-pertensives and normotensives had different performances on three attention networks ( alerting, orienting, and ex-ecutive control). Results Compared with the normotensive group, the visuospatial and executive function,atten-tion,delayed recall and total scores of MoCA were significantly lower in hypertension group,the difference was sta-tistically significant ( P<0. 05 ) . The normotensive group demonstrated greater attention efficiencies than the hyper-tensive participants in the alerting and executive control attention networks(P<0. 05). There were no differences in the orienting attention network,mean reaction time,or accuracy. Conclusion Elderly patients of stage 1 essential hypertension without treatment are significantly lower on the visuospatial and executive function,attention, delayed recall and total scores of MoCA,indicating that hypertensive patients were cognitive dysfunction. Elderly hyperten-sives have a significantly worse performance on the attention networks especially alerting and executive control.