| 缺血性脑卒中后抑郁患者的BDNF及CRH研究 |
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| 引用本文： | 穆夏黎,黄永璐,高宗良,骆鹏飞. 缺血性脑卒中后抑郁患者的BDNF及CRH研究[J]. 安徽医科大学学报, 2015, 0(3): 389-392 |
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| 作者姓名： | 穆夏黎 黄永璐 高宗良 骆鹏飞 |
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| 作者单位： | 安徽医科大学第二附属医院神经内科,合肥,230601;安徽医科大学第二附属医院神经内科,合肥,230601;安徽医科大学第二附属医院神经内科,合肥,230601;安徽医科大学第二附属医院神经内科,合肥,230601 |
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| 摘 要： | 对30例未发生缺血性脑卒中后抑郁(非PSD组)患者及25例PSD组患者于多个时间点行血清脑源性神经生长因子(BDNF)及促肾上腺皮质激素释放激(CRH)检测。对照组为25例健康成年者。组内比较， PSD组血清BDNF及CRH的变化晚于非PSD组。组间比较， PSD组 BDNF各个时间点均显著低于非PSD组， CRH各时间点均显著高于非PSD 组。相关性分析显示， PSD 组患者治疗前， BDNF 与CRH呈负相关性。 BDNF及CRH参与了PSD的发生发展，并且两者具有相互作用关系，动态检测血清BDNF及CRH浓度有可能成为预测PSD发生、指导其治疗的生物学指标。
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| 关 键 词： | 卒中后抑郁 脑源性神经生长因子 促肾上腺皮质激素释放激素 |
A study of BDNF and CRH in patients with post ischemic stroke depression |
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| Abstract: | The stroke patients were divided into PSD group(n=25) and non-PSD group(n=30). The brain de-rived neurophic factor ( BDNF) and corticotropin releasing hormone ( CRH) in all groups were detected at several time points. Compared with the non-PSD group, the PSD group had a significantly higher Serum BDNF and a sig-nificantly lower serum CRH. Correlation analysis showed that BDNF and CRH were negatively correlated in PSD patients before treatment. BDNF and CRH was involved in the development of PSD, both had the interaction rela-tions, dynamic detection of serum BDNF and CRH concentration could predict PSD and guide its treatment. |
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| Keywords: | post-stroke depression brain derived neurophic factor corticotropin releasing hormone |
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