Microglia activation in sepsis: a case-control study |
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| Authors: | Afina W Lemstra Jacqueline CM Groen in't Woud Jeroen JM Hoozemans Elise S van Haastert Annemiek JM Rozemuller Piet Eikelenboom Willem A van Gool |
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| Affiliation: | (1) Department of Neurology, Academic Medical Centre, PO Box 22660, 1100DD Amsterdam, The Netherlands;(2) Department of Neuropathology, Academic Medical Centre, PO Box 22660, 1100DD Amsterdam, The Netherlands |
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| Abstract: | Background infection induces an acute phase response that is accompanied by non-specific symptoms collectively named sickness behavior. Recent observations suggest that microglial cells play a role in mediating behavioral changes in systemic infections. In animal models for sepsis it has been shown that after inducing lipopolysaccharide, LPS, microglia in the brain were activated. The aim of this study was to investigate whether activation of microglia can be detected in patients who died of sepsis. |
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