大肠癌组织中COX-2，iNOS，VEGF的表达及其临床意义

目的探讨COX-2，iNOS，VEGF在大肠癌组织中的表达及其临床意义。方法采用免疫组化方法检测58例大肠癌组织中COX-2，iNOS，VEGF的表达，并分析其临床意义。结果58例大肠癌组织中COX-2，iNOS，VEGF的阳性表达率分别为79．31％（46／58）、84．48％（49／58）和79．31％（46／58），显著高于正常大肠组织（P〈0．01），与患者年龄、有无淋巴结转移、肿瘤体积及组织学类型差异无统计学意义（P〉0．05），COX-2与VEGF的表达存在一定相关性（P〈0．05），COX-2与iNOS的表达也存在一定相关性（P〈0．05）。结论大肠癌组织COX-2、iNOS的表达与肿瘤血管生成密切相关，二者可能与VEGF协同促进肿瘤血管生成，是判断肿瘤恶性程度及预后的的重要生物学指标。

Expression of inducible nitric oxide synthase, cyclooxygenase-2and Vascular endothelial growth factor in human colorectal carcinoma and Their Clinical Significances

Objective To investigate expression of inducible nitric oxide synthase, cyclooxygenase-2and Vascular endothelial growth factor in human colorectal carcinoma and their clinical significances. Methods The expressions of COX-2, iNOS, VEGF in 58 casees of colorectal carcinoma tissue were assessed by immuno-histochemistry, and there relation to there clinical significance were statistically analyzed. Results Positive ex-pression rates of COX-2, iNOS, VEGF in 58 casees of colorectal carcinoma tissue were79.31% (46/58)、 84.48% (49/58),79.31% (46/58), which were significantly higher than that in colorectal tissues, the expres-sions of COX-2,iNOS, VEGF donnot relate to age,lymph node status and the structural type of eolorectal carci-noma(P>0.05). The expression of COX-2was correlated with VEGF and iNOS. (P<0.05). Conclusion COX-2,iNOS may promote angiogenesis through the way of VEGF,they may be important biological markers in evaluateing the malignant degree and prognosis.