复方桔皮油乳剂溶石实验后色素类胆石成分和超微结构变化

应用化学分析、原子吸收光谱及扫描电镜,研究胆色素类结石经复方桔皮油乳剂溶解后的成分及超微结构变化。结果:胆石中胆固醇、胆红素,钙、镁含量均有显著下降,而铜的含量变化不大,胆石钙含量下降率与减重率呈正相关;胆石外层有明显的溶解改变,但胆石基质包裹内的胆石成分无溶解改变。提示:含有丰富苧烯的桔皮油对胆石中的胆固醇成分有确切的溶解作用;在胆石的众多金属元素中,钙是影响溶石效果的关键成分;胆石基质是干扰溶石效果的重要原因。对改善色素类胆石溶石效果的可能途径进行了讨论。

Changes of Compositions and Ultrastructure of Dissolved Pigment Gallstones with the Prescription of Orange Peel Oil

A study on the changes of compositions and ultrastructure of diss- olved pigment gallstones by means of chemical analysis, atomic absorp- tion spectrophotometry and scanning electromicroscopy is reported. The study showed that the amounts of cholesterol, bilirubin, calcium, and magnesium of the gallstones were remarkably reduced with the exception of copper. The calcium reducing rate was in a positive linear correla- tion with the wieght-reducing rate of gallstones. The outer layers of the stones showed obvious dissolution changes, but the parts covered by the gallstone matrices didn't. The above mentioned results indicate that the orange peel oil conta- ining a large amount of Limonene posseses certain dissolution effect on the cholesterol of gallstones. Among the metal elements of gallstones, calcium is the key element affecting the solubility of the stones. An important factor interfering with the solubility of the stones is the ma- trix. The methods which can lead to further improvement of the dis- solution effect on gallstones are alsodiscussed.