高频超声评价颈动脉粥样硬化与冠状动脉病变的关系

目的利用高频超声检测颈动脉内中膜厚度(IMT)、斑块形成情况,并与冠状动脉(冠脉)病变程度的关系进行分析。方法应用ASPEN彩色多普勒超声诊断仪,对428例健康人(对照组)及89例冠心病患者(冠心病组)进行颈动脉IMT、斑块形成的检测。冠心病组患者以冠脉病变支数分为3个亚组。结果冠心病组患者颈动脉IMT为(1.19±0.14)mm,而对照组为(0.92±0.13)mm,(P<0.01);IMT增厚检出率及斑块形成检出率冠心病组为43.21%、74.65%,而对照组为14.49%、34.35%,(P<0.01)。1支冠脉病变组IMT为(1.00±0.014)mm,斑块形成检出率为42.86%;2支冠脉病变组IMT为(1.15±0.018)mm,斑块形成检出率为65.52%;3支及以上冠脉病变组IMT为(1.31±0.018)mm,斑块形成检出率为74.49%,(P<0.01)。结论颈动脉IMT增厚、斑块形成对冠心病具有预测价值;颈动脉IMT增厚、斑块形成与冠脉病变严重程度呈正相关。

Hish-resolution ultrasound evaluation of relation between the carotid atherosclerosis and the severity of coronary artery lesions

Objectives To study the intima-media thickness(IMT) and atherosclerotic plaques of carotid artery in healthy person and patients with coronary heart disease(CHD).To analyse the correlation between the coronary artery atherosclerosis and peripheral artery atherosclerosis.Methods 428 normal volunteers and 89 patients with CHD were enrolled in this study.All of the patients had accepted coronary angiography and the diagnoses of CHD were confirmed.The IMT and atherosclerotic plaques of carotid artery were measured by high resolution ultrasound technique.Results IMT of carotid artery was 1.19±0.14 mm in patients with CHD and was 0.92±(0.13) mm in healthy persons,P<0.01.The rates of detection of IMT thickening and plaques in patient group were(43.21%) and 74.65%,but in normal subjects were 14.49% and 34.35% respectively,P<(0.01.) IMT was 1.00±0.014 mm and rate of detection of plaques was 42.86% in 1 branch coronary artery lesions group.In 2 branch coronary artery lesions group,IMT and rate of detection of plaques were 1.15±(0.018) mm and 65.52% and in 3 branch lesions group,they were 1.31±0.018 mm and 74.49% respectively,P<(0.01.)Conclusion IMT of carotid artery was significantly thicker in patients with CHD than in healthy persons.The rate of detection of plaques was significantly increased in the patients with CHD.IMT and atherosclerotic plaques of carotid artery were positively correlated to the severity of coronary artery lesions in patients with CHD.