不同剂量及给药途径的EP方案治疗非小细胞肺癌的临床研究

目的：探讨不同剂量及途径给药的EP方案对非小细胞肺癌的疗效及不良反应。方法：1998年3月－20003年5月将156例非小细胞肺癌患者随机分为A（40例）、B（36例）、C（42例）、D（38例）4组，并分别予静脉滴注大剂量顺铂加口服足叶乙甙或静脉滴注足叶乙甙，以及静脉滴注小剂量顺铂加口服足叶乙甙或静脉滴注足乙甙组成的EP方案治疗，结果：4例EP方案的有效率分别为45％（18／40）、47．22％（17／36）、45．24％（19／42）、47．37％（18／38）；中位缓解期分别为4月、4．2月、3．8月、3．5月，经统计学分析学分析均无明显差异（P＞0．05）。但其不良反应明显差别（P＜0．05），C组出现白细胞下降，恶心呕吐及脱发反应最少，B组最多。结论：静脉滴注小剂量顺铂加口服足叶乙甙组成的EP方案给药方法简便，不良反应少，而且经济，比较适合年老体弱及经济落后地区非小细胞肺癌患者的姑息性治疗。

Clinic Study of Different Dose-Schedule EP Rigimen in Treatment for Patients with Non-Small Cell Lung Cancer

Objective: The aim of this study was to evaluate the efficacy and toxicity of different dose/schedule EP regimen in treatment of the patients with non small cell lung cancer. Methods: Between March 13,1998 to May 20,2000, 156 cases of non small cell lung cancer were radomized into four groups A(40 cases), B(36 cases), C(42 cases), and D(38 cases),and were respectively treated with Ep regimen of different dosage and port of administration. Results: The response rates in these groups were 45%(18/40),47.22%(17/36),45.24%(19/42),and 47.37%(18/38), respectively. The median remissive times were 4,4.2,3.8 and 3.5 months, respectively,which was not significantly (P >0.05) different. But the toxicity was significantly different (P< 0.05). The incidence of leukopenia, nausea, vomiting, and alopecia of the group C was the lowest,while group B was the highest. Conclusion: Ep regimen of intravenous dripping low dose cisplatin with p.o etoposide for patients with non small cell lung cancer is an active,practical regimen with relatively low toxicity,and it is aspecially suitable for elderly patients and patients who need low cost medical care.