| 调控黑色素瘤转移的新信号蛋白: Syntenin |
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| 引用本文： | Jian-bo Yang,James B. McCarthy. 调控黑色素瘤转移的新信号蛋白: Syntenin[J]. 中南大学学报(医学版), 2007, 32(2): 204-212 |
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| 作者姓名： | Jian-bo Yang James B. McCarthy |
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| 作者单位： | Department of Laboratory Medicine and Pathology and Comprehensive Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA |
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| 基金项目： | This work was supported by National Institutes of Health grants R02CA82295.ACKN0WLEDGEMENTS This work was supported by National Institutes of Health grants R02 CA82295. |
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| 摘 要： | Syntenin蛋白在多种肿瘤中表达增强,最近被认为是一个新的黑色素瘤转移调节因子.作为一类支架信号蛋白,Syntenin通过它的两个PDZ 功能基团可与许多细胞膜受体胞内末端或细胞内的信号分子结合,调控多种重要的细胞生理过程和信号传导途径,包括细胞膜受体的聚集,细胞内蛋白质的转运,细胞骨架的重建,转录因子的激活,以增强肿瘤细胞的生长、黏附以及肿瘤的血管生成、侵袭和转移能力.本文简要综述了syntenin的结构和功能,相关的信号途径,及其在黑色素瘤研究领域的最新进展.
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| 关 键 词： | syntenin PDZ功能基团 信号传导 黑色素瘤转移 |
| 文章编号： | 1672-7347（2007）02-0204-09 |
| 收稿时间： | 2007-03-04 |
| 修稿时间： | 2007-03-04 |
Syntenin: a novel PDZ domain-containing scaffolding proteinassociated with human melanoma metastasis |
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| Jian-bo Yang,James B. McCarthy. Syntenin: a novel PDZ domain-containing scaffolding proteinassociated with human melanoma metastasis[J]. Journal of Central South University. Medical sciences, 2007, 32(2): 204-212 |
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| Authors: | Jian-bo Yang James B. McCarthy |
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| Affiliation: | Department of Laboratory Medicine and Pathology and Comprehensive Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA |
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| Abstract: | |
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| Keywords: | syntenin PDZ domain cell signaling melanoma metastasis |
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