Clinical Observations from a Breast Cancer Registry in Asian Women |
| |
Authors: | Siew-Eng Lim Michael Back Esther Quek Philip Iau Thomas Putti John E L Wong |
| |
Institution: | (1) Department of Hematology-Oncology, National University Hospital, 5 Lower Kent Ridge Rd, Singapore, 119074, Singapore;(2) Department of Radiation Oncology, National University Hospital, 5 Lower Kent Ridge Rd, Singapore, 119074, Singapore;(3) The Cancer Institute, National Healthcare Group, National University Hospital, 5 Lower Kent Ridge Rd, Singapore, 119074, Singapore;(4) Department of Surgery, National University Hospital, 5 Lower Kent Ridge Rd, Singapore, 119074, Singapore;(5) Department of Pathology, National University Hospital, 5 Lower Kent Ridge Rd, Singapore, 119074, Singapore;(6) Department of Medicine, National University of Singapore, National University Hospital, 5 Lower Kent Ridge Rd, Singapore, 119074, Singapore |
| |
Abstract: | Background The incidence of breast cancer in Singapore, reflecting cancer trends of developed nations, is rising rapidly. It is the most
common cancer in Singaporean women. Given the significant problem that breast cancer poses, this study reports the clinical-pathologic
features of 1,165 women with invasive breast cancer managed at a university teaching hospital in Singapore.
Methods All patients who were diagnosed, treated, and followed-up at this institution between 1990 and 2002 were analyzed. Data were
obtained from the National University Hospital Breast Cancer Registry.
Results Of our patients, 82% were ethnic Chinese. The median age of presentation was 49 years, and 24.5% of our patients presented
with stage I disease. In addition, 51% of premenopausal and 60% of postmenopausal patients stained positive for estrogen receptor.
Mastectomy was the most common surgical therapy, and about 90% of patients received adjuvant therapy. At a median follow-up
of 81 months, the median 5-year survival was as follows: stage I, 97%, stage II, 78%, stage III, 52%, and stage IV, 13%.
Conclusions This study supports what has been observed among breast cancer patients in this region and reflects a profile of breast cancer
that differs from that seen in the West: patients present at a younger age, with more advanced stage and fewer estrogen-positive
tumors. Most women in our series received systemic adjuvant therapy, and the 5-year overall survival rates are equivalent
to published results from the West. The unique features of the disease in women in Singapore are important to recognize, as
they may influence future prevention and management strategies for Asian women with breast cancer. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|