甲状腺癌组织CXCR4、Ki-67表达与临床病理特征及预后的关系研究

目的:探讨甲状腺癌组织趋化因子受体4(CXCR4)、Ki-67表达与临床病理特征及预后的关系。方法:选取2017年7月~2019年10月在某院行手术治疗的90例甲状腺癌患者癌组织标本设为研究组,收集癌旁组织标本作为良性组,另外选择同期在我院行手术治疗的90例甲状腺良性病变患者病理标本为对照组。比较3组Ki-67、CXCR4阳性表达率,分析Ki-67、CXCR4阳性表达率与甲状腺癌临床病理特征关系以及Ki-67、CXCR4表达与甲状腺癌患者疾病进展时间(TTP)的相关性。结果:研究组Ki-67、CXCR4阳性表达率高于良性组、对照组,差异有统计学意义(P<0.05);良性组Ki-67、CXCR4阳性表达率与对照组相比,差异无统计学意义(P>0.05);甲状腺癌患者病理分期Ⅲ~Ⅳ期Ki-67、CXCR4阳性表达率高于病理分期Ⅰ~Ⅱ期,有淋巴结转移Ki-67、CXCR4阳性表达率高于无淋巴结转移,且有包膜侵犯Ki-67阳性表达率高于无包膜侵犯,差异有统计学意义(P<0.05);Ki-67、CXCR4阳性者TTP较阴性者高,差异有统计学意义(P<0.05)。结论:Ki-67、CXCR4在甲状腺癌中呈高表达,其表达水平与临床病理特征密切相关,并影响患者术后疾病进展,为甲状腺癌患者的治疗提供新的理论依据。

Relationship between the Expression of CXCR4 and Ki-67 in Thyroid Cancer Tissues and Clinicopathological Characteristics and Prognosis

Objective:To investigate the relationship between the expression of chemokine receptor 4(CXCR4)and Ki-67 in thyroid cancer tissues and clinicopathological characteristics and prognosis.Methods:90 cases of cancer tissues from thyroid cancer patients who underwent surgical treatment in a hospital from July 2017 to October 2019 were selected as the study group,and the specimens adjacent to the cancer tissue were collected as benign group.The pathological specimens of 90 patients with benign thyroid lesions treated by surgery were selected as the control group.The Ki-67 and CXCR4 positive expression rates of the three groups were compared,and the relationship between Ki-67 and CXCR4 positive expression rates and the clinicopathological characteristics of thyroid cancer and the correlation between Ki-67 and CXCR4 expression and the time to disease progression(TTP)of thyroid cancer patients were analyzed.Results:The positive expression rates of Ki-67 and CXCR4 in the study group were higher than those in the benign group and the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the positive expression rates of Ki-67 and CXCR4 in the benign group compared with the control group,without significant difference(P>0.05);Ki-67 and CXCR4 positive expression rates in pathological stages III^IV of thyroid cancer patients were higher than those in pathological stages I^II,and Ki-67 and CXCR4 positive expression rates were higher in patients with lymph node metastasis than in those without lymph node metastasis.Moreover,the positive expression rate of Ki-67 with envelope invasion was higher than that without envelope,with statistically significant difference(P<0.05);Ki-67 and CXCR4 positive patients had higher TTP than negative ones,and the difference was statistically significant(P<0.05).Conclusion:Ki-67 and CXCR4 are highly expressed in thyroid cancer.The expression levels of Ki-67 and CXCR4 are closely related to the clinicopathological characteristics and affect the postoperative disease progression of patients,providing a new theoretical basis for the treatment of patients with thyroid cancer.