阿立哌唑对女性精神分裂症患者服用奥氮平引起的代谢综合征的影响分析

目的:探析阿立哌唑对女性精神分裂症患者服用奥氮平引起的代谢综合征的影响。方法:选取广东省惠州市第二人民医院于2017年5月~2018年5月收治的64例服用奥氮平引起代谢综合征的女性精神分裂症患者作为主要对象,采用数字随机表达法分为观察组和对照组,各32例。观察组采用阿立哌唑治疗,对照组采用利培酮治疗,比较两组代谢综合征及精神症状的治疗效果。结果:治疗前观察组与对照组的腰围、BMI指数、空腹血糖、甘油三酯、高密度脂蛋白等代谢指标无明显差异(P>0.05);治疗后观察组的腰围、BMI指数、空腹血糖、甘油三酯等代谢指标均明显低于对照组(P<0.05);治疗前观察组与对照组的PANSS评分无明显差异(P>0.05),治疗后观察组的PANSS评分明显低于对照组(P<0.05)。结论:阿立哌唑可改善女性精神分裂症患者服用奥氮平引起的代谢综合征,且对精神分裂症的治疗效果佳。

Effect of Aripiprazole on Metabolic Syndrome Induced by Olanzapine in Female Patients with Schizophrenia

Objective:To investigate the effect of aripiprazole on metabolic syndrome induced by olanzapine in female patients with schizophrenia.Methods:64 schizophrenia female patients with metabolic syndrome induced by olanzapine from May 2017 to May 2018 in Huizhou Second People's Hospital of Guangdong Province were selected as the main subjects.They were divided into observation group and control group with 32 cases in each group by digital random expression method.The observation group was treated with aripiprazole and the control group was treated with risperidone.The therapeutic effects of metabolic syndrome and psychiatric symptoms were compared between the two groups.Results:There was no significant difference in waist circumference,BMI index,fasting blood glucose,triglyceride and high density lipoprotein between the two groups before treatment(P>0.05).After treatment,the waist circumference,BMI index,fasting blood glucose and triglyceride in the observation group were significantly lower than those in the control group(P<0.05);and there was no significant difference in PANSS score between the observation group and the control group before treatment(P>0.05).After treatment,the PANSS score of the observation group was significantly lower than that of the control group(P<0.05).Conclusion:Aripipiprazole can improve the metabolic syndrome caused by olanzapine in female schizophrenic patients,and has a good therapeutic effect on schizophrenia.