趋化因子CCL5表达与肾透明细胞癌病理特征及预后的相关性分析

目的:探讨趋化因子CCL5表达与肾透明细胞癌病理特征及预后的相关性分析。方法:回顾性分析2012年1月~2014年1月在某院肿瘤科治疗的100例肾透明细胞癌患者的临床资料,将其作为观察组,将同期100例健康体检者作为对照组,检测并比较两组的趋化因子CCL5水平,分析肾透明细胞癌组织及癌旁组织中CCL5表达的差异性、CCL5与肾透明细胞癌病理特征的关系、CCL5与肾透明细胞癌患者总体生存率的关系。结果:观察组CCL5水平明显高于对照组(P<0.05);肿瘤组织中CCL5表达阴性、弱阳性、中阳性、强阳性的比例与癌旁组织相比有明显差异(P<0.05);CCL5表达与肿瘤病理分期、肿瘤分级、肿瘤大小等密切相关,在分化低、级别高、直径大的肿瘤,CCL5表达越高(P<0.05),而与年龄、性别无显著关联(P>0.05);CCL5高表达的患者生存时间明显低于CCL5低表达的患者(P<0.05)。结论:趋化因子CCL5表达与肾透明细胞癌病理特征及预后有显著相关性,CCL5表达越高,病理恶性程度越高,预后越差,可作为临床评估病情严重程度的监测指标和潜在治疗靶点。

Correlation Analysis between Expression of Chemokine CCL5 and Pathological Features and Prognosis of Renal Clear Cell Carcinoma

Objective:To investigate the correlation between the expression of chemokines CCL5 and the pathological features and prognosis of renal clear cell carcinoma. Methods:The clinical data of 100 patients with clear cell carcinoma of the kidney treated in the oncology department of a hospital from January 2012 to January 2014 were retrospectively analyzed and included as the observation group, and 100 healthy patients during the same period were taken as the control group. The levels of chemokine CCL5 in the two groups were detected and compared, the differences of CCL5 expression in clear cell carcinoma of kidney and adja-cent tissues,the relationship between CCL5 and pathological features of clear cell carcinoma of kidney,and the relationship between CCL5 and overall survival rate of patients with clear cell carcinoma of kidney were analyzed.Results:The level of CCL5 in the observation group was significantly higher than that in the control group(P<0.05).The proportion of negative,weak positive,medium positive and strong positive CCL5 expression in tumor tissues was significantly different from that in adjacent tissues(P<0.05).CCL5 expression is closely related to tumor pathological stage,tumor grade,tumor size,etc.In the tumors with low differentiation,high grade and large diameter,the higher CCL5 expression is(P<0.05),but there is no significant correlation with age and gender(P>0.05).The survival time of patients with high CCL5 expression was significantly lower than that of patients with low CCL5 expression(P<0.05).Conclusion:The expression of chemokines CCL5 is significantly correlated with the pathological characteristics and prognosis of renal clear cell carcinoma.The higher the expression of CCL5,the higher the degree of pathological malignancy and the worse the prognosis,which can be used as a monitoring indicator and potential therapeutic target for clinical evaluation of the severity of the disease.