Effect of substance P on CCK- or VIP-induced choleresis in anesthetized dogs |
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Authors: | INGER MAGNUSSON LARS THULIN |
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Affiliation: | INGER MAGNUSSON (HOLM),LARS THULIN |
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Abstract: | 10 anesthetized dogs were provided with acute common bile duct fistulas and the gallbladder was excluded. Hepatic bile output and biliary content of sodium, potassium and amylase were studied. 6 caval infusions were administered of CCK, 0.3 Ivy U-kg-1 min-1, with a superimposed infusion of SP, 20 ng kg-1 min-1. 7 caval infusions were given of VIP, 50 ng-kg-1 min-1, with a superimposed infusion of SP, 20 ng·kg-1 min-1. CCK increased bile output and biliary content of sodium, potassium and amylase by 78–110%. The corresponding increase induced by VIP was 55–85%. Biliary pH was not influenced. SP abolished the effects of both CCK and VIP. It is suggested that all peptides studied influenced canalicular bile secretion by changing the electrolyte excretion. |
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Keywords: | Substance P CCK VIP choleresis |
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