胃癌组织中程序性死亡受体-1和程序性死亡-配体1表达与临床病理特征及预后的相关性

目的:探讨胃癌组织中程序性死亡受体-1(PD-1)和程序性死亡-配体1(PD-L1)表达情况和临床病理特征、预后相关性。方法:选取2016年2月~2018年2月某院诊治实施手术治疗胃癌患者103例临床资料行回顾性分析,分析癌组织和癌旁组织中PD-1、PD-L1表达阳性率、死亡和存活率,患者癌组织中PD-1、PD-L1表达阳性率,及不同病理分期中PD-1、PD-L1表达阳性率差异。结果:癌组织PD-1和PD-L1表达阳性率显著高于癌旁组织[40.78%vs.0.00%,63.11%vs.0.97%,P<0.05]。死亡患者癌组织中PD-1、PD-L1表达阳性率显著高于存活患者[62.50%vs.21.82%,87.50%vs.43.64%,P<0.05]。不同分化程度、不同TNM分期PD-1表达阳性率无统计学意义(P>0.05)。不同分化程度PD-L1表达阳性率无统计学意义(P>0.05);TNM分期中III^IV期患者PD-L1表达阳性率显著高于I^II期患者[78.85%vs.29.41%,P<0.05]。结论:胃癌组织中PD-1和PD-L1表达水平较高,PD-L1表达水平和病理特征有一定相关性,PD-1和PD-L1与患者预后有一定相关性。

Correlation of Programmed Death Receptor-1 and Programmed Death-Ligand 1 Expression with Clinicopathological Features and Prognosis in Gastric Cancer

Objective:To investigate the clinical and clinicopathological characteristics and prognostic correlation of programmed death receptor-1(PD-1)and programmed death ligand 1(PD-L1)in gastric cancer tissues.Methods:The clinical data of 103 patients with gastric cancer treated by surgery from February 2016 to February 2018 were analyzed retrospectively.The positive rates,death and survival rates of PD-1 and PD-L1 expression in cancer tissues and para-cancer tissues were analyzed,as well as the positive rates of PD-1 and PD-L1 expression in cancer tissues,as well as the differences in the positive rates of PD-1 and PD-L1 expression in different pathological stages.Results:The positive rate of PD-L1 expression in paracancerous tissues was significantly higher than that in paracancerous tissues[40.78%vs.0.00%,63.11%vs.0.97%,P<0.05].The positive rate of PD-1,PD-L1 expression in cancer tissues of dead patients was significantly higher than that of survival patients[62.50%vs.21.82%,87.50%vs.43.64%,P<0.05].There was no significant difference in the positive rate of PD-1 expression in different differentiation degrees and different TNM stages(P>0.05).There was no significant difference in the positive rate of PD-L1 expression in different degrees of differentiation(P>0.05).The positive rate of PDL1 expression in TNM stage III^IV patients was significantly higher than that in patients with phase I to II[78.85%vs.29.41%,P<0.05].Conclusion:PD1 and PDL1 expression levels in gastric cancer tissues were high,the expression level of PD-L1 is correlated with the pathological features,while PD-1 and PD-L1 are correlated with the prognosis of patients.