大肠腺瘤与不同分化大肠癌患者血清中LEA及CEA的表达比较

 目的　探讨LEA和CEA在大肠腺瘤与不同分化大肠癌间的关系。方法　用双抗夹心ELISA技术 ,检测大肠腺瘤 16例、不同分化大肠癌 93例及正常人 32例血清中LEA和CEA。结果　LEA在大肠腺瘤的阳性率分别与高、中分化大肠癌间的阳性率无显著性差异 (P >0 .0 5 ) ,与低分化癌的阳性率存在显著性差异 (P <0 .0 5 ) ;而CEA在大肠腺瘤的阳性率分别与高、中、低不同分化大肠间的阳性率无显著性差异 (P>0 .0 5 ) ;结论　LEA在大肠腺瘤的表达可作为分化程度较高的大肠癌癌前病变的指标

The comparison of expression of LEA and CEA in the serum of colorectal adenoma and different differentiated colorectal carcinoma patients

Objective To explore the relationship of LEA and CEA between colorectal adenoma and different differentiated colorectal carcinoma. Methods Using sandwich ELISA technology, LEA and CEA are separately detected in serum of 16 colorectal adenoma, 93 different differentiated colorectal carcinoma and 32 normal people. Result LEA positive rate among colorectal adenoma and well, moderately differentiated colorectal carcinoma has no significant difference ( P >0.05). LEA positive rate of colorectal adenoma is significantly different from poorly differentiated colorectal carcinoma ( P <0.05); while CEA positive rate of colorectal adenoma is not significantly different from that of well, moderately or poorly different differentiated colorectal carcinoma( P >0.05).Conclusion LEA expression in colorectal adenoma may be regarded as a marker of pre|cancerous lesion in comparatively well|differentiated colorectal carcinoma.