皮肤MALT淋巴瘤缺乏t(11;18)(q21;q21)/API2-MALT1和t(14;18)(q34;q21)/IGH—MALT1 |
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引用本文: | 周英琼,宫丽平,侯巧燕,肖胜军,郭芳,叶洪涛. 皮肤MALT淋巴瘤缺乏t(11;18)(q21;q21)/API2-MALT1和t(14;18)(q34;q21)/IGH—MALT1[J]. 广西医科大学学报, 2009, 26(2): 197-199 |
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作者姓名: | 周英琼 宫丽平 侯巧燕 肖胜军 郭芳 叶洪涛 |
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作者单位: | 1. 桂林医学院附属医院病理科,桂林,541001 2. 首都医科大学病理系 |
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基金项目: | 国家自然科学基金,广西自然科学基金,广西病理学人才小高地创新团队资助项目 |
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摘 要: | 目的:探讨黏膜相关淋巴组织(MALT)淋巴瘤中常见的两个染色体易位t(11;18)(q21;q21)/API2-MALT1和t(14;18)(q34;q21)/IGH—MALT1在皮肤MALT淋巴瘤中的发生率。方法:采用MALT1及IGH双色分离探针,对19例皮肤MALT淋巴瘤标本进行间期荧光原位杂交(FISH)。结果:19例皮肤MALT淋巴瘤中均未检测到涉及MALT1基因的染色体易位,但发现2例(2/19,11%)存在MALT1基因的3个拷贝现象。结论:涉及MALT1基因的染色体易位,即t(11;18)(q21;q21)/API2-MALT1和t(14;18)(q34;q21)/IGH—MALT1在皮肤MALT淋巴瘤罕见或不见。
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关 键 词: | 皮肤 MALT淋巴瘤 染色体易位 FISH |
ABSENCE OF t(11;18)(q21;q21)/API2-MALT1 AND t(14;18)(q34;q21)/IGH-MALT1 IN PRIMARY CUTANEOUS MALT LYMPHOMA |
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Affiliation: | Zhou Yingqiong, Gong Liping, Hou Qiaoyan, et al. (Department of Pathology, Guilin Medical College, Guangxi 541001 China) |
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Abstract: | Objective.t(ll;18)(q21;q21)/API2-MALT1 and t(14;18)(q34;q21)/IGH-MALT1 have been reported in cutaneous MALT lymphoma. However, the incidence of t(11;18)(q21;q21)/API2-MALT1 and t(14;18)(q34;q21)/IGH-MALT1 in this kind of cutaneous lymphoma remains unclear. Methods. 19 cases of cutaneous MALT lymphoma were screened by interphase FISH analysis using MALT1 and IGH break apart probes. Results: The translocations involving MALT1 were not detected in all of the 19 cutaneous MALT lymphoma, but 3 copies of MALT1 gene were detected in two of the 19 cases (11%) . Conclusion:This study demonstrated that translocations involving MALT1 gene, including API2-MALT1 and IGH-MALT1 are absence or at least uncommon in cutaneous MALT lymphoma. |
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Keywords: | FISH |
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