Molecular pathways regulating the formation of brown‐like adipocytes in white adipose tissue |
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| Authors: | Huiqin Zhang Yushan Mao Anshi Wang Xin Wang Zuquan Zou Xiaohong Zhang |
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| Affiliation: | 1. Institute of Preventative Medicine and Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, School of Medicine, Ningbo University, Ningbo, Zhejiang, China;2. The Affiliated Hospital of School of Medicine of Ningbo University, Ningbo University, Ningbo, Zhejiang, China |
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| Abstract: | Adipose tissue is functionally composed of brown adipose tissue and white adipose tissue. The unique thermogenic capacity of brown adipose tissue results from expression of uncoupling protein 1 in the mitochondrial inner membrane. On the basis of recent findings that adult humans have functionally active brown adipose tissue, it is now recognized as playing a much more important role in human metabolism than was previously thought. More importantly, brown‐like adipocytes can be recruited in white adipose tissue upon environmental stimulation and pharmacologic treatment, and this change is associated with increased energy expenditure, contributing to a lean and healthy phenotype. Thus, the promotion of brown‐like adipocyte development in white adipose tissue offers novel possibilities for the development of therapeutic strategies to combat obesity and related metabolic diseases. In this review, we summarize recent advances in understanding the molecular mechanisms involved in the recruitment of brown‐like adipocyte in white adipose tissue. Copyright © 2014 John Wiley & Sons, Ltd. |
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| Keywords: | brown like adipocyte uncoupling protein 1 white adipose tissue thermogenesis |
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