| 垂体肿瘤转化基因和血管内皮生长因子在肝硬化和肝癌中的表达及其临床意义 |
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| 引用本文： | 石祥呈,康凯夫,陈小伍,车爱文,陈坚平.垂体肿瘤转化基因和血管内皮生长因子在肝硬化和肝癌中的表达及其临床意义[J].肿瘤研究与临床,2008,20(2):94-96. |
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| 作者姓名： | 石祥呈 康凯夫 陈小伍 车爱文 陈坚平 |
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| 作者单位： | 1. 广东医学院病理教研室,524023
2. 广东省佛山市顺德区第一人民医院病理科 |
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| 基金项目： | 广东省佛山市科研项目 |
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| 摘 要： | 目的 分析垂体肿瘤转化基因(PTTG)和血管内皮生长因子(VEGF)在原发性肝细胞肝癌(HCC)中的表达并探讨其相互关系.方法 应用原位杂交法和免疫组织化学SP法检测HCC组织50份、肝硬化组织30份、正常肝组织10份中PTTG和VEGF的表达.结果 PTTG和VEGF在HCC、月干硬化中的表达差异有统计学意义(P＜0.05).10份正常对照均为阴性.结论 PTTG和VEGF异常表达与肝癌、肝硬化的发展密切相关,对肿瘤血管生成起着重要作用,可为肝癌的早期诊断和治疗提供客观的参考指标.
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| 关 键 词： | 肝肿瘤 肝硬化 垂体肿瘤转化基因 血管内皮生长因子 癌基因 |
| 收稿时间： | 2007-4-24 |
Expression of PTTG and VEGF in cirrhosis tissues and hepatocellular carcinoma and their clinical significance |
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| SHI Xiang-cheng,KANG Kai-fu,CHEN Xiao-wu,CHE Ai-wen,CHEN Jian-ping.Expression of PTTG and VEGF in cirrhosis tissues and hepatocellular carcinoma and their clinical significance[J].Cancer Research and Clinic,2008,20(2):94-96. |
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| Authors: | SHI Xiang-cheng KANG Kai-fu CHEN Xiao-wu CHE Ai-wen CHEN Jian-ping |
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| Institution: | SHI Xiang-cheng[1] KANG Kai-fu[2] CHEN Xiao-wu[2] CHE Ai-wen[2] CHEN Jian-ping[2] |
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| Abstract: | Objective To investigate the relationship between expressions of PTTG, VEGF genes and oncogenesis in human hepatocellular carcinomas(HCC). Methods The expressions of PTTG and VEGF in 50 cancer tissues, 30 cirrhosis tissues and 10 normal tissues were assessed by in situ hybridization and immunohistochemical methods. Results The expressions of PTTG and VEGF in cancer tissues, cirrhosis tissues were significantly different (P <0.05). The expressions of normal tissue were negative. Conclusion The abnormal expression of PTTG and VEGF were closely associated with the development of liver cancer. They may play an important role in the blood vessel of tumors. They can be used as indicators for early diagnosis and treatment for hepatocellular carcinoma. |
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| Keywords: | Liver cirrhosis Pituitary tumor-transforming gene Vascular endothelial growth factor Oncogene |
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