磷酸喹哌对实验性心律失常的作用初报

磷酸喹哌(Piperaqune phosphate,PQP)ip 18mg/kg 对氯仿诱发小白鼠室颤具有保护作用,iv PQP 9 mg/kg 明显降低氯化钙所致小鼠室颤的死亡率,iv PQP 3.36mg/kg 明显缩短肾上腺素诱发家兔心律失常的持续时间。ivPQP6.3mg/kg 显著增加恒速滴注乌头碱引起麻醉大鼠室性早搏(VE)、室性心动过速(VT),室性纤颤(VF)所需的乌头碱用量。结果提示 PQP 具有抗心律失常作用。小白鼠 iv PQP LD_(50)为93.33mg/kg。

EFFECT OF PIPERAQUINF PHOSPHATE ON EXPERIMENTAL ARRHYTHMIA

18mg/kg of Ip piperacuine phosphate(PQP)prevented mice from chloro- form-induced ventricular fibrillation.9mg/kg of PQP iv markedly decresed the mortality of mice given iv CaCl_2 130g/kg.3.36mg/kg of PQP iv markedly shortened the duration of arrhythmia elicited by 50ug/kg of iv epinephrine in unanesthetized rabbits.In the anesthetized rats 6.3mg/kg of PQP iv significantly elevated the dosage of aconitine(2/ug/0.2ml/min iv) required to induce ventricular extrasystole(VE),ventricular tachycardia (VT)and ventricular fibrillation(VF).The results suggested that PQP exerted antiarrhythmic actions.The iv LD50 of PQP was 93.33mg/kg.