急性心肌梗塞早期MRI与病理对照研究

将１６支结扎冠状动脉左前降支的犬分为两组。第一组９只，第二组７只，分别进行手术前和术后３０ｍｉｎ到３ｈ的ＭＲ平扫和Ｇｄ－ＤＴＰＡ增强扫描。观察其ＭＲＩ征象，并与病理改变相对照。平扫组部分犬出现心前壁高信号和腔内流动信号，而增强组７只犬在注射Ｇｄ－ＤＴＰＡ后３～３０ｍｉｎ均有增强效应，其信号增强区与相对应层面的心肌大切片ＴＴＣ染色所示梗塞区大小形态相同。结果表明Ｇｄ－ＤＴＰＡ增强ＭＲＩ能够敏感可靠地显示早期心肌梗塞。

Correlative Study between MRI and Pathology in Early Phrase of Acute Myocardial Infarction

Sixteen mongrel dogs were divided into 2 groups. After ligation of the left anterior descending artery (LAD), 9 dogs were put into the first group of plain scanning and 7 dogs were in the second group of enhanced MR scanning. Plain MRI studies were performed before ligation and both plain and enhanced MRI were performed 30 min, 60 min, 120 min and 180 min after ligation respectively. MRI features were studied and were correlated with pathologic changes. On plain MRI the local hyperintensity in the anteror myocardial wall could be clearly found,There was also hyperintensity of the intraventricular blood flow. All of the 7 dogs in the second group showed enhancement areas and the quantity and shape of the enhancement areas correlated well with the infarction area of the pathologic specimen. The result indicated that Gd-DTPA enhanced MRI is very sensitive and specific to the detection of early phrase acute myocardial infarction