| P物质对慢痛引起的脊髓背角神经元电活动的影响 |
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| 引用本文： | 阮怀珍,李希成,蔡文琴. P物质对慢痛引起的脊髓背角神经元电活动的影响[J]. 第三军医大学学报, 1997, 0(1) |
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| 作者姓名： | 阮怀珍 李希成 蔡文琴 |
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| 作者单位： | 第三军医大学基础部生理学教研室 |
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| 摘 要： | 目的：观察Ｐ物质（ＳＰ）及其受体阻断剂Ｓｐａｎｔｉｄｅ对Ｗｉｓｔａｒ大鼠脊髓背角神经元自发放电和伤害性慢痛放电的影响。方法：采用多管微电极细胞外记录和离子微电泳方法。结果：①电泳ＳＰ可使脊髓背角神经元单位放电增多，其效应可被Ｓｐａｎｔｉｄｅ阻断。②电泳ＳＰ又可抑制福尔马林引起的神经元伤害性痛放电，此效应可被纳洛酮和Ｓｐａｎｔｉｄｅ翻转。结论：在痛觉调制过程中，脊髓内ＳＰ起着传递痛觉信息和镇痛的双重作用。
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| 关 键 词： | P物质；脊髓背角；离子电泳；单位放电 |
Effects of substance P on slow pain induced electrical activity of neurons in the spinal dorsal horn |
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| Ruan Huaizhen,Li Xicheng,Cai Wenqin. Effects of substance P on slow pain induced electrical activity of neurons in the spinal dorsal horn[J]. Acta Academiae Medicinae Militaris Tertiae, 1997, 0(1) |
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| Authors: | Ruan Huaizhen Li Xicheng Cai Wenqin |
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| Abstract: | Objective: To observe the effects of substance P (SP) and its receptor blocker, spantide, on the spontaneous discharge and injurious slow pain discharge of the neurons in the spinal dorsal horn. Methods: Extracellular recording with multimicropipetes and iontophoresis were employed for the observation in Wistar rats. Results: (1) The unit discharge of the spinal dorsal horn was increased after the iontophoresis of SP, which could be blocked with spantide; (2) The formalin induced injurious slow pain discharge of the spinal dorsal horn could be inhibited by iontophoresis of SP and the inhilition could be reversed with naloxone and spantide. Conclusion: SP plays double roles of pain transmission and analgesia in pain modulation. |
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| Keywords: | substance P iontophoresis unit discharge spinal dorsal horn |
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