| Ca~(2+)在大鼠应激性胃粘膜损伤中作用的研究 |
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| 引用本文： | 杨永杰,王强,石镇霞,陈悦.Ca~(2+)在大鼠应激性胃粘膜损伤中作用的研究[J].河南大学学报(医学版),2002,21(1):8-9. |
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| 作者姓名： | 杨永杰 王强 石镇霞 陈悦 |
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| 作者单位： | 河南大学医学院,生理教研室,河南,开封,475001 |
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| 摘 要： | 目的 :探讨大鼠胃粘膜与急性胃粘膜损伤之间的关系。方法 :采用原子吸收光谱分析法 ,测定胃粘膜Ca2 +含量。结果 :胃粘膜损伤程度随应激时间延长而加重 ,胃粘膜Ca2 + 含量却下降 ,二者呈明显负相关 ,但是 ,CaCl2 预应激或应用钙通道阻断剂 ,可减轻胃粘膜损伤程度。结论 :Ca2 + 在急性胃粘膜损伤中有一定的作用。
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| 关 键 词： | Ca2+ 胃粘膜损伤 研究 |
| 文章编号： | 1008-2867(2002)01-0008-02 |
| 修稿时间： | 2001年9月21日 |
Study on Role of Ca2 + in Rats Gastric Mucosal Lesion Induced by Stress |
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| YANG Yong_jie,WANG Qiang,SHI Zhen_xia,CHEN Yun.Study on Role of Ca2 + in Rats Gastric Mucosal Lesion Induced by Stress[J].Journal of Henan University,2002,21(1):8-9. |
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| Authors: | YANG Yong_jie WANG Qiang SHI Zhen_xia CHEN Yun |
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| Abstract: | Objective: To study the relationship between acute lesins of gastric mucosal and changes in the contents of Ca 2+ in Rats.Methods: Atom absorption spectrum analysis was used to examine the dynamic changes in the contents of Ca 2+ in the gastic mucosa.Results: Gastric mucosal damage density in stress rats was gradually increased with the lengthenging of stress time, whereas gastric mucosal contents of Calcium was gradually decreased. Both the contents of Calcium and gastric mucosal lesion showed a significant negative correlation.But administration of CaCl 2 prior to stress or using blocker of Ca 2+ channeles could reduce gastric mucosal lesion.Conclusion: Ca 2+ may play a role in the acute gastric mucosal lesion. |
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| Keywords: | Ca 2+ gastric mucosal lesions study |
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