肺癌患者血清可溶性细胞间黏附分子-1水平变化及其临床意义

目的探讨肺癌患者不同临床分期、组织学类型和分化程度血清可溶性细胞间黏附分子水平,化疗前后此项指标的变化,从而判断血清可溶性细胞间黏附分子以及其与肺癌发展、临床分期、治疗疗效的关系。方法对41例肺癌患者、20例良性肺病患者和20例正常人用ELISA方法检测了血清细胞间黏附分子水平。分析不同临床分期、病理类型和分化程度的血清细胞间黏附分子水平以及化疗前后血清细胞间黏附分子的变化。结果①肺癌组与良性肺病组、正常对照组比较;肺癌组和良性肺病组血清细胞间黏附分子水平均升高,差异无显著性。两者与正常对照组比较,差异有显著性。②Ⅱ、Ⅲ期血清细胞间黏附分子升高,与Ⅰ期比较,差异有显著性。③不同病理类型的血清细胞间黏附分子水平比较,差异无显著性;不同分化程度血清细胞间黏附分子水平比较,差异无显著性。④化疗后血清细胞间黏附分子水平降低,经配对t检验,差异有显著性。结论早期肺癌患者sICAM-1水平即可升高,属肺癌发生和发展过程中的早期分子事件,且随着肺癌分期的进展而逐渐升高。检测血清sICAM-1变化可为判断肺癌的自然病程和预后提供一种较为客观的指标。

The Level and Clinical Significance of sICAM in Lung Carcinoma Patients

Objective To studythe level of serum sICAM in different clinical stages、pathological types and diverse differentiation of lung carcinoma patients.To search changes of the there signs before and after chemotherapy and their correlation.To consider whether sICAM will be related to the progression and clinical stage of lung carcinoma.Methods Detect the level of serum sICAM in 41 lung carcinoma patients、20 benign lung disease patients and 20 normal person by ELISA method.Assay the changes of the there signs in different clinical stages、pathological types and diverse differentiation of lung carcinoma.Observe the chagnes of the there signs before and after chemotherapy.Results 1.Compare lung carcinoma cases with benign lung disease cases and normal person:the sICAM level is high in both lung carcinoma and benign lung disease.the difference is not significant.But compare with normal person,the difference is significant.2.the level of sICAM in ⅡⅢ stages is higher than in Ⅰ stage,the difference is significant.3.compare the level of serum sICAM with each other in different pathological types,the difference is not significant.4.compare the level of serum sICAM with each other in diverse differentiation cases,the difference is notsignificant.5.the changes of serum sICAM after chemotherapy decline.The difference is significant by means of paired T test.Conclusion As the levels of serum sICAM rises in earlier stages.Serum sICAM will probably be the signs of diagnosis in earlier lung carcinoma.Then the change of serum sICAM will be the sign of observation of treatment and prognosis of lung carcinoma.