胸腔内注入纤维蛋白原和凝血酶治疗难治性自发性气胸

目的:探讨纤维蛋白原和凝血酶胸腔内注入治疗难治性自发性气胸的疗效。方法:将112例难治性自发性气胸患者随机分为治疗组和对照组,每组各56例,治疗组予经胸腔闭式引流管先后注入纤维蛋白原和凝血酶,注药后观察疗效及不良反应。对照组进行持续胸腔闭式引流,部分辅助以用持续负压吸引等常规内科治疗。治疗组和观察组疗程均为3～4周。结果:治疗组有效率为91.2%,对照组为51.4%;平均住院时间治疗组为(13±5.61)d,对照组为(16±5.34)d,两组比较差异均有统计学意义(P<0.01),同时两组不良反应率都较低。结论:胸腔内注入血浆和凝血酶治疗难治性气胸具有有效率高、住院天数少、不良反应极少等优点,值得临床推广。

Infusion of fibrinogen and thrombin into leural cavity in the treatment of comlicated sontaneous neumothorax

Objective To evaluate the curative effect of fibrinogen and thrombin infusion in the treatment of comlicated sontaneous neumothorax.Methods 56 cases of comlicated sontaneous neumothorax were randomly divided intoexeriment grou and control grou.Exeriment grou have been infused with fibrinogen and thrombin into leural cavity.Curative effect and side effect were monitored after infusion.Results The effective rate of exeriment grou was significantly better than that of control grou（P〈0.01）.Hositalization days of exeriment grou were fewer than that of control grou.Side effect in exeriment grou was mild.Conclusion Fibrinogen and thrombin infusion is effective and safe in thetreatment of comlicated sontaneous neumothorax.