米非司酮配伍米索前列醇终止早孕出血原因的研究

探讨采用配伍方法进行药物流产后出血时间长的原因。方法一组２２例，服米非司酮及米索前列醇药物流产，二级２０例采用吸宫术终止妊娠。分别于妊囊排出或吸宫后第５、１４、２４天抽肘静脉血测血ｈＣＧ、Ｐ、Ｅ２ＦＳＨ、ＬＨ及ＰＲＬ，同时记录出血时间。

Study on Causes of Bleeding in Induced Abortion by Ru486 Combined With Misoprostol

Objective To study the causes for long time bleeding in drug induced abortion. Methods 42 cases were assigned randomly to two groups, 22 cases of early pregnancy were terminated by administration of Ru486 and misoprostol, and 20 cases were performed by uterine aspiration. The serum levels of hCG, E 2, P, FSH, LH and PRL were detected in all cases in the 5 th , 14 th and 24 th day after excretion of the pregnant sac or uterine aspiration,and the bleeding duration was recorded simultaneously. Results Serum hCG decreased slowly in Ru486 group and its levels in the 14 th and 24 th day after abortion were obviously higher than that in uterine aspiration group. Although there was no significant difference in E 2 level between the two group, the E 2 values in Ru486 group were lower than those in uterine aspiration group in the measured days. The serum levels of P, LH, FSH and PRL had no marked differences in each time ( P >0.05). Conclusions The long duration and large amount of bleeding in early termination of pregnancy by Ru486 combined with misoprostol were correlated with slow denudation of the uterine decidua, slow decrease of hCG, and slow endometrial repair ment by insufficient E 2.