| 依托度酸的合成 |
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| 引用本文： | 赵丽华,耿佃云. 依托度酸的合成[J]. 中国医药工业杂志, 2005, 36(12): 730-731 |
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| 作者姓名： | 赵丽华 耿佃云 |
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| 作者单位： | 1. 淄博职业学院化工系,山东,淄博,255013
2. 淄博万昌集团,山东,淄博,255424 |
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| 摘 要： | 7-乙基色醇和3-氧代戊酸甲酯以甲醇为溶剂,在浓硫酸作用下缩合得到1,8-二乙基-1,3,4,9-四氢吡喃并[3,4-b]吲哚-1-乙酸甲酯,再经碱性水解制得依托度酸,总收率77%,纯度大于99.5%.
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| 关 键 词： | 依托度酸 非甾体抗炎药 合成 |
| 文章编号： | 1001-8255（2005）12-0730-02 |
| 收稿时间： | 2005-01-06 |
| 修稿时间： | 2005-01-06 |
Synthesis of Etodolac |
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| ZHAO Li-Hua,GENG Dian-Yun. Synthesis of Etodolac[J]. , 2005, 36(12): 730-731 |
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| Authors: | ZHAO Li-Hua GENG Dian-Yun |
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| Affiliation: | 1. Chemical Engineering Dept. of Zibo Vocational College, Zibo 255013; 2. Zibo Wanchang Group, Zibo 255424 |
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| Abstract: | Etodolac was synthesized from 7-ethyltryptophol and methyl 3-oxopentanonate by condensation inconc. H2SO4-CH3OH to give methyl 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetate followed by hydrolysis in77% overall yield and purity of 99.5%. |
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| Keywords: | etodolac non-steroid anti-inflammatory drug synthesis |
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