| 通里攻下法药理作用的进一步探讨 |
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| 引用本文： | 王文俊,姚智.通里攻下法药理作用的进一步探讨[J].中国中西医结合外科杂志,1995,1(2):111-112. |
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| 作者姓名： | 王文俊 姚智 |
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| 作者单位： | [1]天津市中西医结合急腹症研究所 [2]天津第二医学院免疫教研室 |
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| 摘 要： | 大承气汤是通里攻下法的代表方剂，在急腹症中应用范围很广，已取得明显效果。为进一步探讨其抗炎、抗休克等药理作用的分子机制，本实验于体外观察了大承气汤对单核巨噬细胞分泌细胞因子的影响。结果发现大承气汤能激活正常人单核细胞（ｍｏｎ）及小鼠腹腔巨噬细胞（ＭΦ）分泌肿瘤坏死因子α（ＴＮＦα）、白细胞介素１及６（ＩＬ－１，ＩＬ－６），同时还能抑制由内毒素诱导的上述因子的过量分泌。从而进一步证实了大承气汤抗炎及
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| 关 键 词： | 大承气汤 内毒素 细胞因子 通里攻下法 |
Further Study on the Mechanism of Purgative Therapy |
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| Wang Wen-jun,Cui Nai-qiang,Wu
Xian-zhong,et al..Further Study on the Mechanism of Purgative Therapy[J].Chinese Journal of Surgery of Integrated Traditional and Western Medicine,1995,1(2):111-112. |
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| Authors: | Wang Wen-jun Cui Nai-qiang Wu
Xian-zhong |
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| Abstract: | e
observed the effect of Da Cheng Qi Tang on end otoxin-induced monocyte andmacrophage
secretion of TNF,IL-1,IL-6. In the result we found that Da Cheng Qi Tang couldinhibit cytokines
secretion induced by endotoxin.We also found that Da Cheng QiTang couldstimulate monocyte to
secret cytokines.So it was further proved that Da Cheng Qi Tang has thefunctions of
anti-inflan1mation, anti-septic shock and of improving blood circulation,and has pos-sible
molecular mechanism. |
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| Keywords: | Da chang Qi Tang endotoxin cytokines |
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