急性白血病患者血清、脑脊液IL-6水平及临床意义

目的：探讨IL-6在急性白血病患者血清及脑脊液中的变化、病情及预后的关系。方法：用放射免疫分析检测了急性白血病患者（38例）和正常健康人（30例）血清和脑脊液IL-6水平，对治疗前后、病情变化进行了比较。结果：1．急性白血病患者治疗前血清和脑脊液IL-6水平都明显高于正常组（P〈0．01），治疗缓解后比治疗前明显降低（P〈0．01）；2．急性白血病患者复发或发生脑膜白血病后血清和脑脊液IL-6水平升至更高；3．急性白血病IL-6水平与白血病细胞负荷有着较好的正相关性；4．脑脊液中IL-6浓度明显升高是诊断脑膜白血病的早期敏感指标。结论：检测急性白血病患者血清和脑脊液IL-6水平，有助于了解患者的病情变化及其预后。

Clinical Significance of Alterations in the Serum and CSF Levels of IL-6 in Patients with Acute Leukemia

Objective To study the clinical significance of alterations in the serum and cerebrospinal fiuid(CSF) levels of IL-6 in patients with acute leukemia(AL).Methods Serum and CSF IL-6 levels were measured with radioimmunoassay in 38 patients with AL before and after treatment and in several patients during relapse after treatment as well as in 30 controls.Results(1) The serum and CSF levels of IL-6 in patients with AL before treatment were significantly higher than those in controls(P<0.01).Of the same group patients the serum and CSF levels of IL-6 after treatment were significantly lower than those before treatment(P<0.01).(2) Levels of IL-6 in serum and CSF in patients during relapse or with CNS involvement(CNSL) were even higher than those before treatment.(3) Serum levels of IL-6 in patients with AL were well correlated with the magnitude of tumor burden.(4) CSF IL-6 is an early and sensitive indicator in detecting CNSL with AL.Conclusion Dynamic!changes in serum and CSF IL-6 levels can be utilized as an indicator of therapeutic effect as well as prognosis.