二甲双胍联合达因-35治疗多囊卵巢综合征的疗效评价

目的探讨二甲双胍联合达因一35对多囊卵巢综合征患者促排卵治疗疗效的影响。方法将2008年1月～2012年2月我科收治的64例多囊卵巢综合征患者随机分为两组。观察组32例，患者先接受二甲双胍联合达因一35治疗，持续治疗3个月经周期后再接受尿促性素一绒促性素（HMG—HCG）促排卵治疗；对照组32例，患者先接受达因一35治疗，持续治疗3个月经周期后再接受HMG—HCG促排卵治疗。结果①治疗前两组患者促黄体生成素（LH）、卵泡雌激素（FSH）、睾酮（T）、雌二醇（E2）、空腹胰岛素（FINS）、体质指数（BMI）相比差异无统计学意义（P〉O．05）；治疗后观察组的LH、T、FINS、BMI显著降低（P〈0．05），FSH、E2治疗前后相比差异无统计学意义（P〉0．05）；对照组的LH、T显著降低（P〈0．05），FSH、E2、FINS、BMI治疗前后相比差异无统计学意义（P〉0．05）；观察组LH、T的降低幅度大于对照组（P〈0．05）。②观察组的排卵率、妊娠率显著高于对照组（P〈0．05）。结论二甲双胍联合达因一35可促进HMG—HCG疗法对多囊卵巢综合征患者的促排卵作用。

The efficacy of Metformin combined with Diane-35 in the treatment of patients with polycystic ovary syndrome:An evaluation of therapeutic efficacy

Objective To investigate the effect of metformin combined with Diane-35 on ovulation induction in patients with polycystic ovary syndrome.Methods Sixty-four patients with polycystic ovary syndrome who were admitted into our department from January 2008 to February 2012 were divided into two groups,observation group(n=32) received metformin combined with Diane-35 for 3 menstrual cycles firstly,and then was given human menopausal gonadotropin-human chorionic gonadotropin(HMG-HCG) for ovulation induction,while control group(n=32) received Diane-35 for 3 menstrual cycles firstly,and then was given HMG-HCG for ovulation induction.Results(1)Before treatment,there were no significantly differences in hormone luteinizing(LH),follicle stimulating hormone(FSH),testosterone(T),Estradiol(E2),fasting insulin(FINS) and body mass index(BMI) between observation group and control group(P>0.05).After treatment,the LH,T,FINS,BMI in observation group decreased significantly(P<0.05),and FSH,E2 didn’t change significantly(P>0.05);the LH,T in control group decreased significantly(P<0.05),and FSH,E2,FINS,BMI didn’t change significantly(P >0.05);the reduction extent of LH and T in observation group were significantly larger than those in control group,respectively(P<0.05).(2)The ovulation rate and the pregnancy rate of observation group were significantly higher than those of control group,respectively(P<0.05).Conclusion Metformin combined with Diane-35 is able to improve the ovulation induction by HMG-HCG in patients with polycystic ovary syndrome.