急性髓系白血病中CD64表达的敏感性及特异性研究

研究急性髓系白血病(AML)免疫分型中CD64的敏感性和特异性.用系列抗原对132例AML患者的骨髓细胞进行直接标记,并用流式细胞术进行分析.结果表明:在AML中,CD64对急性粒-单细胞白血病(M4)和急性单核细胞白血病(M5)中敏感性最高(分别为96.4%和100%),在其他AML(M0、M1、M2、M3,M6、M7)中表达均较低.CD64对M4和M5中的特异性为56.5%.因此,CD64有助于AML中M4、M5的鉴别诊断.

A Study of Sensitivity and Specificity of CD64 Expression in Acute Myeloid Leukemia

To study the sensitivity and specificity of CD64 in immunotyping of acute myeloid leukemia(AML).The bone marrow cells from 132 patients with AML were labelled with a series of antigens and were analyzed by flow cytometry.CD64 has high sensitivity in patients with acute myelomonocytic leukemia(M4) 96.4% and acute monocytic leukemia(M5)(96.4% and 100%,respectively).The expressions of CD64 was very low on patients with other kinds of AML(M0,M1,M2,M3,M6,M7).The specificity of CD64 in patients with M4 and M5 was 56.5%.The results suggest that the CD64 is helpful in the differential diagnosis of M4 and M5 in AML patients.