| 肝移植术后丙型肝炎病毒的再感染与丙肝复发 |
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| 引用本文： | 王秋虹,黄洁,田大广,胡明道,魏小平,寸冬云. 肝移植术后丙型肝炎病毒的再感染与丙肝复发[J]. 中华肝胆外科杂志, 2010, 16(12). DOI: 10.3760/cma.j.issn.1007-8118.2010.12.026 |
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| 作者姓名： | 王秋虹 黄洁 田大广 胡明道 魏小平 寸冬云 |
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| 摘 要： | 丙肝肝炎后肝移植病人均伴随不同程度的丙型肝炎病毒(HCV)复发,其发病机制因疾病的不同阶段而不同.影响复发的因素包括HCV基因型、病毒载量、供体和受体HLA匹配情况、复发的时间、供体的年龄等,而免疫抑制剂的使用是最重要的影响因素.治疗的效果通过持续病毒学应答来评价.目前认为聚二乙醇干扰素联合利巴韦林是治疗慢性丙型肝炎最好的选择和最佳的治疗方案.
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| 关 键 词： | 丙型肝炎病毒复发 肝脏移植术后 持续病毒学应答 |
HCV re-infection and hepatitis C recurrence after liver transplantation |
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| WANG Qiu-hong,HUANG Jie,TIAN Da-guang,HU Ming-dao,WEI Xiao-ping,CUN Dong-yun. HCV re-infection and hepatitis C recurrence after liver transplantation[J]. Chinese Journal of Hepatobiliary Surgery, 2010, 16(12). DOI: 10.3760/cma.j.issn.1007-8118.2010.12.026 |
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| Authors: | WANG Qiu-hong HUANG Jie TIAN Da-guang HU Ming-dao WEI Xiao-ping CUN Dong-yun |
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| Abstract: | Different degrees of HCV re-infection exist in patients with hepatitis C after liver transplantation. Its pathogenesis is different according to different phases of the disease. Factors affecting its recurrence include HCV gene type, viral load, HLA matching between donor and recipient, time of recurrence, donor's age and so on, in which the application of immunosuppressants is the most important influencing factor. The virological response can be used to evaluate the effects of treatment. Now, it is widely accepted that the best choice and therapeutic plan is Pegy interferon alfa-2a/2b combined with Ribavirin. |
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| Keywords: | HCV recurrence Post-liver transplantation Sustained virological response |
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