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血清标志物联合检测在肺癌诊断中的应用研究(附60例报告)
引用本文:李菊,胥海永,赵忠峰. 血清标志物联合检测在肺癌诊断中的应用研究(附60例报告)[J]. 哈尔滨医药, 2010, 30(4): 16-17
作者姓名:李菊  胥海永  赵忠峰
作者单位:1. 山东省莱芜市莱城区口镇卫生院,山东,莱芜,271114
2. 山东省莱芜市中医医院,山东,莱芜,271100
摘    要:目的探讨血清中肿瘤标志物胃泌素释放肽前体(Pro-GRP)、水溶性细胞角蛋白19片段(CYFRA21-1)、血管内皮生长因子(VEGF)和癌胚抗原(CEA)在肺癌诊断中的应用。方法健康对照组70例,肺癌组80例,均同时检测Pro-GRP、GYFRA21-1、VEGF和CEA。结果肺癌组Pro-GRP、CYFRA21-1、VEGF、CEA和对照组比较,差异有统计学定义(P〈0.01)。且CYFRA21-1、VEGF、CEA在非小细胞肺癌中的敏感性和诊断准确性较高。结论血清肿瘤标志物能敏感、特异地进行肺癌的诊断,并对肺癌的分型有重要主义。

关 键 词:胃泌素释放肽前体  水溶性细胞角蛋白19片段  血管内皮生长因子  癌胚抗原  非细胞肺癌

Serum Markers in the Diagnosis of Lung Cancer(Report of 60 cases)
LI Ju,XU Hai-yong,ZHAO Zhong-feng. Serum Markers in the Diagnosis of Lung Cancer(Report of 60 cases)[J]. harbin medical journal, 2010, 30(4): 16-17
Authors:LI Ju  XU Hai-yong  ZHAO Zhong-feng
Affiliation:1.Laiwu City,Shandong Province Town City Health Center,Laiwu 271114,China;2.Laiwu City,Shandong Province Chinese Medicine Hospital,Laiwu 271100,China)
Abstract:Objective Tumor markers in serum gastrin releasing peptide(Pro-GRP) Water-soluble cytokeratin 19 fragment(CYFRA21-1) vascular endothelial growth factor(VEGF) and carcinoembryonic antigen(CEA) in diagnosis of lung cancer application.Methods 70 cases of healthy control group,80 cases of lung cancer group were also detected Pro-GRP,GYFRA21-1,VEGF and CEA.Results of lung cancer group Pro-GRP,CYFRA21-1,VEGF,CEA,and the control group,the difference was the definition of(P〈0.01).And CYFRA21-1,VEGF,CEA in non-small cell lung cancer in a high sensitivity and diagnostic accuracy.Conclusion Serum tumor markers can be sensitive and specific for the diagnosis of lung cancer,and type of lung cancer has important doctrine.
Keywords:Gastrin-releasing peptide  Soluble cytokeratin 19 fragment  Vascular endothelial growth factor  Carcinoembryonic antigen  Non-cell lung cancer
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