| 子宫肌瘤组织在注入甲氨蝶呤后的病理学改变 |
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| 引用本文： | 苑洪菲,伏胜香,崔红艳,孙淑清,薛红艳,车丽萍. 子宫肌瘤组织在注入甲氨蝶呤后的病理学改变[J]. 武警医学, 2005, 16(3): 187-189 |
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| 作者姓名： | 苑洪菲 伏胜香 崔红艳 孙淑清 薛红艳 车丽萍 |
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| 作者单位： | 武警黑龙江总队医院妇产科,哈尔滨,150076 |
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| 摘 要： | 目的探讨子宫肌瘤在注入MTX(甲氨蝶呤)后缩小的机制.方法对5例子宫肌瘤在注入MTX半个月及1个月后行手术治疗,对其标本进行了光镜和电镜观察并与同期未注药标本进行了比较.结果所有注入MTX的标本光镜下,均可见明显的平滑肌细胞的水肿、变性,单位视野内的血管数目明显减少,血管腔变窄;电镜下见平滑肌细胞内变性、水肿、扩张的内质网和线粒体等.结论 MTX的缩瘤效果是通过减少肌瘤内的血供和直接的细胞凋亡来完成的.
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| 关 键 词： | 子宫肌瘤 药物治疗 超微结构 |
| 收稿时间： | 2004-12-28 |
| 修稿时间： | 2004-12-28 |
Pathological changes in hysteromyoma after injection of methotraxate |
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| YUAN Hongfei,FU Shengxiang,CUI Hongyan,SUN Shuqing,XUE Hongyan,CHE Liping. Pathological changes in hysteromyoma after injection of methotraxate[J]. Medical Journal of the Chinese People's Armed Police Forces, 2005, 16(3): 187-189 |
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| Authors: | YUAN Hongfei FU Shengxiang CUI Hongyan SUN Shuqing XUE Hongyan CHE Liping |
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| Affiliation: | YUAN Hongfei,FU Shengxiang,CUI Hongyan,SUN Shuqing,XUE Hongyan,and CHE Liping.Department of Obstetics and Gynecology,Heilongjiang Provincial Corps Hospital,Chinese People's Armed Police Forces,Harbin 150076,China |
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| Abstract: | Objection To study the mechanism of shrinkage of hystero myoma after injectiong methotraxate (MTX).Methods Five patients with hysteromyoma under went operative treatment half a month and one month after injection of MTX .The tumr specimens were examined under light microscope and electron microscope, and compared with those specimens without injection of MTX.Results Light microscopically,all the MTX injected specimens showed edema and degeneration in smooth muscle cells.Electron microscopically,degerated,edematous and dilated endoplasmic reticula and mitochondria in smooth muscle cells were visualized.Conclusion The effect of MTX on shrink age of hystero Myoma is achieved by direct cell apoptosis and blood supply reduction. |
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| Keywords: | Hysteromyoma Methotraxate Pathological change |
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