Effect of immunosuppressive factor produced by human lung cancer cell line A549 on the production and action of interleukin 1 |
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Authors: | Feng Zuo-hua Zhang Gui-mei Hao Tian-ling Chen Zhao-cong Jiang Zhi-yao |
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Affiliation: | 1. Department of Medical Molecular Biology, Tongji Medical University, Wuhan
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Abstract: | A549, a human lung cancer cell line, spontaneously produces a tumor-derived immunosuppressive factor (TDSF) which inhibits the production and action of interleukin 1 (IL-1). After exposure of macrophages to TDSF for 5 h, the production of IL-1 by macrophages was significantly inhibited. The inhibition was much stronger if TDSF existed continuously in macrophage culture. The response of thymocytes treated with nylon wool to exogenous IL-1 was significantly suppressed in the presence of TDSF, suggesting that TDSF can inhibit the action of IL-1. The thymocytes untreated with nylon wool could proliferate after being stimulated with Con A. The proliferation was significantly suppressed by TDSF in a dose-dependent manner. These results suggest that the inhibitory action of TDSF on T cell activation is associated with IL-1, and that TDSF might exert an inhibitory action on other reactions mediated by IL-1. Furthermore, TDSF can reduce the supplementation of new T cells by inhibiting the proliferation of thymocytes. |
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Keywords: | A549 cell tumor-derived immunosuppressive factor interleukin 1 thymocyte |
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