Specific monoamine exchange in the brains of young and aged male rats with hypothyroidism |
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| Authors: | Yu O Fedotova O O Masalova |
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| Institution: | (1) Department of Physical Medicine and Rehabilitation, Taipei Medical University-Shuang Ho Hospital, Taipei, Taiwan;(2) Community Medicine Research Centre and Institute of Public Health, National Yang-Ming University, Taipei, Taiwan;(3) Department of Psychiatry, Far Eastern Memorial Hospital, Taipei, Taiwan;(4) Department and Institute of Physiology, School of Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong Street, Taipei, 11221, Taiwan, ROC;(5) Graduate Institute of Injury Prevention, Taipei Medical University, Taipei, Taiwan; |
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| Abstract: | We analyzed monoamine exchange in different brain structures of young (2-month-old) and aged (22–24 month-old) male rats under
conditions of thyroid hormone (TH) deficit or 14-day-long intraperitoneal (T3) administration of triiodothyronine at a dose of 70 μg/kg. The contents of monoamines and their metabolites were assayed
using HPLC with an electrochemical detector. In the brain structures directly related to animal behavior a TH deficit resulted
in changes in monoamines, which depended on the ages of the rats. During experimental hypothyroidism, the most substantial
changes in the contents and turnover of norepinephrine, dopamine, and serotonin were observed in the brains of young male
rats. In aged animals, a TH deficit increased impairments in neurotransmitter exchange. Substitutive T3 administration did not improve monoamine exchange in the brain structures of young male rats with hypothyroidism. In the
aged rats with hypothyroidism, T3 administration restored monoamine exchange only in the hippocampus but not in other brain structures. |
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