| 都可喜人体药动学研究 |
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| 引用本文： | 刘蕾,李可欣,孙春华,史爱欣,赫广威,李雯京,宋友华.都可喜人体药动学研究[J].中国药学杂志,2000,35(5):326-329. |
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| 作者姓名： | 刘蕾 李可欣 孙春华 史爱欣 赫广威 李雯京 宋友华 |
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| 作者单位： | 卫生部北京医院临床药理基地(刘蕾!北京100730，李可欣!北京100730，孙春华!北京100730，史爱欣!北京100730，赫广威!北京100730)，河北太行集团公司职工医院药剂科(李雯京!河北056200，宋友华!河北056200) |
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| 摘 要： | 目的：研究10名健康志愿者口服都可喜(阿米三嗪/萝巴新)后阿米三嗪和萝巴新的药动学。方法：分别采用高效液相色谱法紫外检测器和高效液相色谱法荧光检测器测定血装中阿米三嗪和萝巴新浓度，结果：经3P87药动学计算程序处理拟合，两者皆符合口服给药二室开放模型，其药动学参数为：阿米三嗪的AUC为(34174.91士2335.17)μg·h·L-1，tmax为(3.81士0.76)h，cmax为(816.76±70.07)μg·L-1；萝巴新的AUC为(1116.15士81.85)μg·h·L-1，tmax为(1.27士0.22)h，ctmax为（374.04±71.1）μg·L-1。结论：此研究为临床提供了药动学参数及生物利用度研究的方法。
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| 关 键 词： | 阿米三秦 萝巴新 都可喜 药动学 |
| 收稿时间： | 1998-08-31; |
Pharmacokinetics of Duxil in healthy volunteers |
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| Liu Lei.Pharmacokinetics of Duxil in healthy volunteers[J].Chinese Pharmaceutical Journal,2000,35(5):326-329. |
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| Authors: | Liu Lei |
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| Institution: | (Liu L),Li Kexin (Li KX),Sun Chunhua (Sun CH |
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| Abstract: | OBJECTIVE:The pharmacokinetics of Duxil (almitrine/raubasine) were studied in ten healthy volunteers after a single oral dose. METHODS:The plasma concentrations of almitrine and raubasine were determined by means of high performance liquid chromatography. RESULTS:The concentration time curves of almitrine and raubasine were fitted to a 2 compartment model.The pharmacokinetic parameters of almitrine and raubasine were calculated as following:almitrine:AUC(34174.91±2335.17) μg·h·L-1,tmax(3.81±0.76) h,cmax(816.76±70.07) μg·L-1;raubasine:AUC(1116.15±81.85) μg·h·L-1,tmax(1.27±0.22) h,cmax(374.04±71.71) μg·L-1. CONCLUSION:This study provides the pharmacokintic parameters for clinical and is benefical to rational use of duxil. |
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| Keywords: | almitrine raubasine Duxil pharmacokintics |
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