大肠癌术后早期营养支持对免疫功能的影响

目的 研究大肠主后肠外营养支持早期机体免疫功能的变化。方法 对60例大肠癌病人根治术后，随机分为试验组（TPN组）和对照组（非TPN组）。分别于手术前，术后1d及术后8d检测IgG、IgA、IgM、C3、T细胞亚群。结果 大肠癌病人术前均有不同程度的免疫功能低下，术后第1天，IgG、IgA、IgM、C3较术前显著下降，术后8dTPN组IgG、IgA、C3恢复较快，达到或超过术前水平，与非TPN组比较差异有显著意义（P＜0．01）。CD3^ 、CD4^ 、CD4^ /CD8^ 比值术后第1天下降明显，而TPN组术后8d迅速恢复并超过术前水平，与非TPN组相比差异有显著意义（P＜0．01）。结论 大肠癌病人术后早期免疫功能低下，应用TPN可以有效的改善机体的免疫功能。

Early Changes in Immunity after Postoperative Parenteral Nutrition in Colon orRectum Cancer Patients (An Analysis of 60 Cases)

Objective To study the early changes in immunity after postoperative nutrition in colon or rectum cancer patients.Methods 60 patients with colon or rectum cancer were divided into two groups at random, namely TNP group and control group. On day 1 before operation, day 1 after operation and day 8 after operation, IgG, IgA, IgM, C 3, T-Cell subgroups were detected.Results The immune function of patients with colon or rectum cancers was deficient at different levels. On day 1 after operation, IgG, IgA, IgM, C 3 decreased more significantly as compared with those before operation. On day 8 post operation, IgG, IgA, C 3 of TPN group recovered rapidly and might reach or exceed the preoperative levels. Compared with non-TPN group, the difference was significant ( P< 0.01). CD 3, CD 3, CD 4/CD 8 ratio decreased significantly on day 1 post operation, but in TNP group, they recovered rapidly and exceeded the preoperative level, the difference between them being significant ( P< 0.01).Conclusion The early immune function of patients with colon or rectum cancer is deficient after operation, and the use of TNP can improve immune function of patients.