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| 天荔汤对糖尿病大鼠早期肾脏高滤过的影响 | |
| 引用本文： | 陈国昌,张灼,彭海东,欧阳忠兴. 天荔汤对糖尿病大鼠早期肾脏高滤过的影响[J]. 中国中医药信息杂志, 2011, 18(8): 30-32. DOI: 10.3969/j.issn.1005-5304.2011.08.012 |
| 作者姓名： | 陈国昌 张灼 彭海东 欧阳忠兴 |
| 作者单位： | 1. 首都医科大学附属北京妇产医院,北京,100026 2. 中国人民解放军第二炮兵总医院,北京,100088 3. 中国人民解放军第二军医大学长征医院,上海,200433 4. 湖北中医学院,湖北武汉,430061 |
| 摘 要： | 目的观察天荔汤对糖尿病大鼠早期肾脏高滤过的影响。方法随机取8只大鼠作为正常组,余52只大鼠用四氧嘧啶诱导糖尿病大鼠模型,以血糖值在13～25 mmol/L者为成模,按血糖高低随机分为模型组、西药组和天荔汤高、低剂量组,每组8只,并给与相应药物。4周后检测大鼠血糖、肾质量、体质量、肾小球滤过率（GFR）及血浆一氧化氮（NO）、内皮素（ET）变化。结果与正常组相比,模型组血糖、尿量、肾质量、体质量、GFR、肾质量与体质量比值（KW/BW）等指标明显增高（P〈0.01）。天荔汤高、低剂量组及西药组均能降低GFR,高剂量组与西药作用相当。天荔汤高剂量组能明显降低肾质量（P〈0.01）,并接近正常。天荔汤高剂量组KW/BW指数明显降低,优于天荔汤低剂量组与西药组（P〈0.01）。结论天荔汤可明显改善糖尿病大鼠肾脏高滤过反应。 |
| 关 键 词： | 糖尿病肾病 天荔汤 肾小球滤过率 一氧化氮 内皮素 大鼠 |
Effects of Tianli Decoction on Glomerular Hyperfiltration in Early Diabetic Rats |
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| CHEN Guo-chang,ZHANG Zhuo,PENG Hai-dong,OUYANG Zhong-xing. Effects of Tianli Decoction on Glomerular Hyperfiltration in Early Diabetic Rats[J]. Chinese Journal of Information on Traditional Chinese Medicine, 2011, 18(8): 30-32. DOI: 10.3969/j.issn.1005-5304.2011.08.012 | |
| Authors: | CHEN Guo-chang ZHANG Zhuo PENG Hai-dong OUYANG Zhong-xing |
| Affiliation: | CHEN Guo-chang1,ZHANG Zhuo2,PENG Hai-dong3,OUYANG Zhong-xing4(1.Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100026,China,2.The Second Artillery General Hospital of PLA,Beijing 100088,3.Changzheng Hospital,The Second Military Medical University of PLA,Shanghai 200433,4.Hubei College of TCM,Wuhan 430061,China) |
| Abstract: | Objective To observe the effect of Tianli Decoction on glomerular hyperfiltration in early diabetic rats kidney.Methods With 8 rats as normal group,52 rats were induced to diabetic model by alloxan.Thirty-two rats of blood glucose levels in 13-25 mmol/L were randomly divided into Tianli Decoction high dose group,Tianli Decoction low dose group,Captopril group,model group according to blood glucose level.Each group had 8 rats and was given corresponding drug.After 4 weeks,blood glucose,kidney hypertrophy,glo... |
| Keywords: | diabetic nephropathy Tianli Decoction glomerulur filtration rate NO ET rats |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |