| HPLC研究异牡荆苷在大鼠体内的药代动力学及组织分布(英文) |
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| 引用本文： | 闫冲,林励,刘红菊,张延娇,陈雅慧. HPLC研究异牡荆苷在大鼠体内的药代动力学及组织分布(英文)[J]. 中国药学, 2011, 20(4): 376-382. DOI: 10.5246/jcps.2011.04.047 |
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| 作者姓名： | 闫冲 林励 刘红菊 张延娇 陈雅慧 |
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| 作者单位： | 广州中医药大学中药学院;广东医学院药学院; |
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| 基金项目： | Foundation for Distinguished Young Talents in Higher Education of Guangdong and Foundation for Young Scholars of Guangdong Medical College(Grant No XQ0802) |
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| 摘 要： | 本文建立了异牡荆苷在大鼠血浆及不同组织中的高效液相色谱检测方法,采用RP-C18色谱柱（250mm×4.6mm,5.0μm）,以甲醇-1%冰醋酸溶液（40:60,v/v）为流动相,柱温为30℃,检测波长为338nm。通过专属性、精密度、线性、准确度、稳定性、提取回收率、最低定量限等方法学考察,证实本方法可对血浆及不同组织中的异牡荆苷进行准确检测。在此方法的基础上研究了异牡荆苷在大鼠体内的药代动力学及组织分布特征。大鼠在静脉注射异牡荆苷后,在预定的时间点取样检测。结果显示异牡荆苷在高、中、低剂量（18.75,3.75,0.75mg/kg）药代动力学特征符合二室模型,在所研究的剂量范围内AUC与给药剂量呈现良好的线性相关性,符合线性动力学特征。药物t1/2α为1.54-1.84min,t1/2β为36.94-46.27min。异牡荆苷在组织中的浓度分布从高到低分别为肾>肝>肺≈卵巢>心≈脾>脑。
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| 关 键 词： | 高效液相色谱法 异牡荆苷 药代动力学 组织分布 |
Study on pharmacokinetic and tissue distribution ofisovitexin in rats by HPLC |
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| Chong Yan,Li Lin,Hong-Ju Liu,Yan-Jiao Zhang,Ya-Hui Chen .School of Chinese Traditional Medicine,Guangzhou University of Chinese Medicine,Guangzhou ,China .School of Pharmacy,Guangdong Medical College,Dongguan ,China. Study on pharmacokinetic and tissue distribution ofisovitexin in rats by HPLC[J]. Journal of Chinese Pharmaceutical Sciences, 2011, 20(4): 376-382. DOI: 10.5246/jcps.2011.04.047 |
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| Authors: | Chong Yan Li Lin Hong-Ju Liu Yan-Jiao Zhang Ya-Hui Chen .School of Chinese Traditional Medicine Guangzhou University of Chinese Medicine Guangzhou China .School of Pharmacy Guangdong Medical College Dongguan China |
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| Affiliation: | Chong Yan~(1,2),Li Lin~(1*),Hong-Ju Liu~2,Yan-Jiao Zhang~2,Ya-Hui Chen~2 1.School of Chinese Traditional Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510006,China 2.School of Pharmacy,Guangdong Medical College,Dongguan 523808,China |
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| Abstract: | |
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| Keywords: | HPLC Isovitexin Pharmacokinetics Tissue distribution |
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