| 白细胞介素-8-251A/T多态性与宫颈癌的相关性 |
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| 引用本文： | 曹党恩,贺国洋,鲁霞.白细胞介素-8-251A/T多态性与宫颈癌的相关性[J].新乡医学院学报,2011,28(4):440-442. |
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| 作者姓名： | 曹党恩 贺国洋 鲁霞 |
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| 作者单位： | 1. 大冶市人民医院妇产科,湖北大冶,435100
2. 新乡医学院病理学教研室,河南新乡,453003 |
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| 摘 要： | 目的探讨白细胞介素-8(IL-8)-251A/T多态性及mRNA与宫颈癌发病的相关性。方法采用聚合酶链反应-限制性片段长度多态性方法检测219例宫颈癌患者(宫颈癌组)和295例健康对照者(对照组)IL-8-251A/T多态性。结果宫颈癌组和对照组均发现IL-8-251A/T位点基因多态性,均可见TT、AT和AA基因型;宫颈癌组TT、AT、AA基因型频率分别为31.1%、49.3%和19.6%,A、T等位基因频率分别为44.3%和55.7%;对照组TT、AT、AA基因型频率分别为42.7%、45.1%和12.2%,T、A等位基因频率分别为65.3%和34.7%;宫颈癌组IL-8-251A/T基因型及等位基因频率与对照组比较,差别有统计学意义(χ2=0.953,572.428;P=0.009,0.000)。结论 IL-8-251A/T多态性与宫颈癌的发病具有相关性。
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| 关 键 词： | 白细胞介素-8 单核苷酸多态性 宫颈癌 |
Association between-251A/T polymorphism of interleukin-8 gene and cervical cancer |
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| CAO Dang-en,HE Guo-yang,LU Xia.Association between-251A/T polymorphism of interleukin-8 gene and cervical cancer[J].Journal of Xinxiang Medical College,2011,28(4):440-442. |
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| Authors: | CAO Dang-en HE Guo-yang LU Xia |
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| Institution: | CAO Dang-en1,HE Guo-yang2,LU Xia1 |
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| Abstract: | Objective To investigate the association between interleukin-8(IL-8)-251A/T polymorphism and cervical cancer.Methods The polymorphism of IL-8-251A/T were analyzed in 219 patients with cervical cancer(cervical cancer group) and 295 healthy person(control group) by polymerase chain reaction restriction fragment length polymorphism.Results The genetypes of TT,AT and AA were present in both cervical cancer group and control group for IL-8-251A/T gene polymorphism.The frequency of each genetype was 31.1%(TT),49.... |
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| Keywords: | interleukin-8 mononucleotide polymorphism cervical cancer |
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