| 金芪降糖片对糖尿病大血管并发症患者内皮细胞功能及炎症因子的影响 |
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| 引用本文： | 王滨,赵红艳,张涌,杨绍祥,周苏宁.金芪降糖片对糖尿病大血管并发症患者内皮细胞功能及炎症因子的影响[J].中国中医药信息杂志,2011,18(7):15-17. |
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| 作者姓名： | 王滨 赵红艳 张涌 杨绍祥 周苏宁 |
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| 作者单位： | 1. 山东大学附属济南市中心医院,山东济南,250013
2. 山东中医药大学,山东济南,250013 |
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| 摘 要： | 目的观察金芪降糖片对糖尿病大血管并发症患者血管内皮细胞及炎症因子的影响。方法将40例2型糖尿病合并大血管并发症患者随机分为2组。对照组20例,采用西药常规治疗;中药组20例,在西药常规治疗基础上加金芪降糖片8片,每日3次。治疗周期3个月。观察治疗前后患者空腹血糖（FBG）、餐后2 h血糖（2 h PG）、血脂、糖化血红蛋白（HbA1c）、内皮素-1（ET-1）、细胞间黏附分子-1（ICAM-1）、肿瘤坏死因子-α（TNF-α）、P-选择素水平。结果 2组治疗后FBG、2 h PG、HbA1c均明显下降（P〈0.05）,组间HbA1c差异有统计学意义（P〈0.05）。中药组治疗后三酰甘油、低密度脂蛋白胆固醇明显下降,高密度脂蛋白胆固醇明显上升,与对照组比较差异有统计学意义（P〈0.05）。中药组治疗后ET-1、ICAM-1、TNF-α、P-选择素水平明显下降,较对照组差异有统计学意义（P〈0.01）。结论金芪降糖片具有显著的降糖作用,改善糖尿病的脂代谢紊乱,可以减轻血管内皮细胞的损伤和抑制炎症因子水平。
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| 关 键 词： | 糖尿病血管并发症 金芪降糖片 血管内皮细胞功能 炎症因子 |
Effect of Jinqi Jiangtangpian on Vascular Endothelial Cells Functions and Inflammatory Factors in Diabetes Mellitus Patients with Macrovascular Complications |
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| WANG Bin,ZHAO Hong-yan,ZHANG Yong,YANG Shao-xiang,ZHOU Su-ning.Effect of Jinqi Jiangtangpian on Vascular Endothelial Cells Functions and Inflammatory Factors in Diabetes Mellitus Patients with Macrovascular Complications[J].Chinese Journal of Information on Traditional Chinese Medicine,2011,18(7):15-17. |
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| Authors: | WANG Bin ZHAO Hong-yan ZHANG Yong YANG Shao-xiang ZHOU Su-ning |
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| Institution: | WANG Bin1,ZHAO Hong-yan1,ZHANG Yong1,YANG Shao-xiang1,ZHOU Su-ning2(1.Center Hospital of Jinan Affiliated to Shandong University,Jinan 250013,China,2.Shandong University of TCM,China) |
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| Abstract: | Objective To observe the protection effect of Chinese traditional medicine on the vascular endothelial cells and inflammatory factors in diabetes mellitus(DM) with macrovascular complications patients.Methods Forty patients of type 2 DM with macrovascular complications was randomly divided into two groups:control group,twenty patients with conventional treatment;treatment group,twenty with conventional medicine and Jinqi Jiangtangpian,3 tablets,3 times a day.The treatment cycle was 3 months.Before and after... |
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| Keywords: | diabetic vascular complications Jinqi Jiangtangpian vascular endothelial cells functions inflammatory factor |
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