Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR |
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| Authors: | Antonia H. Tolson |
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| Affiliation: | Department of Pharmaceutical Sciences, The University of Maryland School of Pharmacy, 20 Penn Street, Baltimore MD 21201, USA |
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| Abstract: | |
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| Keywords: | AKR, aldo-keto reductase AhR, aryl hydrocarbon receptor CES, carboxylesterase CAR, constitutive androstane/activated receptor CYP, cytochrome P450 CCRP, cytoplasmic CAR retention protein CITCO, 6-(4-chlorophenyl) imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl) oxime DEX, dexamethasone DBD, DNA-binding domain DR3/4, direct repeat 3/4 DME, drug-metabolizing enzyme ER, estrogen receptor ER6/8, everted repeat 6/8 FXR, farnesoid X receptor GR, glucocorticoid receptor IR0, inverted repeat 0 LBD, ligand-binding domain LXR, liver X receptor MDR1, multidrug-resistance MRP, multidrug resistance-associated protein Nrf2, nuclear factor-erythroid 2-related factor 2 GST, glutathione S-transferase NR, nuclear receptor OATP, organic anion transporting polypeptide PB, phenobarbital PK11195, 1-(2-chlorophenyl-N-methylpropyl)-3-isoquinoline-carboxamide PXR, pregnane X receptor PPAR, proxisome proliferator activated receptor PCN, pregnenolone 16alpha-carbonitrile RIF, rifampicin SULT, sulfotransferase TCDD, 2,3,7,8-tetrachlodibenzo-p-dioxin TCPOBOP, 1,4-bis[2-(3,5-dichlorpyridyloxy)]benzene UGT, uridine-5'-diphosphate glucuronosyl transferase XREM, xenobiotic responsive element |
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