Phage display technology for stem cell delivery and systemic therapy |
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Authors: | Staquicini Fernanda I Sidman Richard L Arap Wadih Pasqualini Renata |
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Affiliation: | a David H. Koch Center, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USAb Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA |
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Abstract: | Advances in the technology for phage display in vivo have set the stage for a new ligand-directed pharmacology with broad implications for both treatment and molecular imaging of patients, and for the elucidation of molecular mechanisms of action, particularly in carcinogenesis. This technology identifies specific molecular complexes, mainly small peptide and gene-based therapeutic and imaging agents, effective in experimental animals and patients. The unbiased identification of molecular targets on the surfaces of blood vessels and parenchymal cells in preselected specific organs and tissues raises the prospect of an increased understanding of animal and human cellular and vascular proteomics. In this review, we focus on the delivery of phage-based agents via stem and progenitor cells, important delivery vehicles contributing to the growing impact of phage display on modern medicine. |
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Keywords: | AAV, adeno-associated virus CNS, central nervous system DNA, deoxyribonucleic acid [18F]-FEAU, 2&prime -[18F]fluoro-5-ethyl-1-β- smallcaps" >d-arabinofuranosyluracil [18F]-FHBG, 9-(4-[18F]fluoro-3-(hydroxymethyl)butyl)guanine GFAP, glial fibrillary acidic protein HIV, human immunodeficiency virus HSV-tk, herpes simplex virus thymidine kinase [124I-FIAU], 2&prime -fluoro-2&prime -deoxy-5-[124I]iodo-1b- smallcaps" >d-arabinofuranosyluracil ICSP, induced conditional self-renewing progenitor cells IL-11Rα, interleukin 11 receptor alpha iPS, induced pluripotent stem cells LTR, long terminal repeats MCAM, melanoma cell adhesion molecule NCI, National Cancer Institute NSC, neural stem cell OB, olfactory bulb PET, positron emission tomography RMS, rostral migratory stream RNA, ribonucleic acid |
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