Development and applications of photo-triggered theranostic agents |
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| Authors: | Prakash Rai Xiang Zheng Youssef Mir Ahmat Khurshid Tayyaba Hasan |
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| Affiliation: | a Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, United Statesb Harvard Science and Technology, Harvard MIT, Boston MA, 02114, United Statesc Department of Physics and Applied Mathematics, Pakistan Institute of Engineering and Applied Sciences, PO Box 45650, Nilore, Islamabad, Pakistan |
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| Abstract: | Theranostics, the fusion of therapy and diagnostics for optimizing efficacy and safety of therapeutic regimes, is a growing field that is paving the way towards the goal of personalized medicine for the benefit of patients. The use of light as a remote-activation mechanism for drug delivery has received increased attention due to its advantages in highly specific spatial and temporal control of compound release. Photo-triggered theranostic constructs could facilitate an entirely new category of clinical solutions which permit early recognition of the disease by enhancing contrast in various imaging modalities followed by the tailored guidance of therapy. Finally, such theranostic agents could aid imaging modalities in monitoring response to therapy. This article reviews recent developments in the use of light-triggered theranostic agents for simultaneous imaging and photoactivation of therapeutic agents. Specifically, we discuss recent developments in the use of theranostic agents for photodynamic-, photothermal- or photo-triggered chemotherapy for several diseases. |
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| Keywords: | 3-(PhS)4-PcAlOH, hydroxyaluminium tetra-3-phenylthiophthalocyanine Ag, silver ALA, 5-aminolevulinic acid AlPcS4, phthalocyanine tetrasulfonate Au, gold BDP-MA, benzoporphyrin derivative monoacid ring A BLM, bleomycin C11Pc, Zn(II)-phthalocyanine disulphide C60, fullerene CdSe, cadmium selenide CE, contrast-enhanced CNT, carbon nanotubes CPT, camptothecin CR, complete regression CT, computed tomography CVD, cardiovascular disease Dac, daclizumab DDS, drug delivery system DMNB, dimethoxy-2-nitrobenzyl DO3A, 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid DOX, doxorubicin DPBF, 1,3-diphenylisobenzofuran DTPA, diethylenetriaminepentaacetic acid E. coli, Escherichia coli EGFR, epidermal growth factor receptor EPR, enhanced permeability and retention Er3+, erbium Eu, europium FDA, food and drug administration Fe3O4, iron oxide FITC, (fluorescein 5(6)-isothiocyanate) FR, folate receptor FRET, fluorescence resonance energy transfer EtNBS, carboxybutylamino diethylaminobenzo phenothiazinium GLUT, glucose transporter Gd, gadolinium GNP, gold nanoparticle GNT, gold coated carbon nanotube GNR, gold nanorod HA, hyaluronic acid HAuNS, hollow gold nanosphere HGN, hollow gold nanoshell HFF-1, human foreskin fibroblasts HP, hematoporphyrin HPPH, pyropheophorbide-alpha-hexyl-ether HSA, human serum albumin i.c., intracranial ICG, indocyanine green i.p., intra peritoneal IR, infra red i.v., intra venous LAMS, light-activated mesostructured silica LbL, layer-by-layer L-BPD, liposomal benzoporphyrin derivative monoacid ring A LCST, lower critical solution temperature β-LEAP, β-lactamase enzyme-activated photosensitizer LDL, low-density lipoprotein LDLR, LDL receptors Lip-NP, liposome-nanoparticle assembly LMB, leuko methylene blue Ln, lanthanides MB, methylene blue Mce6, mesochlorin e6 MDR, multi drug resistance MFNP, magnetofluorescent nano particle MRI, magnetic resonance imaging MRSA, methicillin-resistant Staphylococcus aureus MSNP, mesoporous silica nanoparticle MTCNPs, magnetic targeting chitosan NPs MTCP, meso-tetra(4-carboxyphenyl) porphine mTHPC, meso-tetra(hydroxyphenyl) chlorine MTT, 3-(4,5-dimethyltiazol-2-yl)-2,5-diphenyltetrazolium bromide MWNT, multi wall carbon nanotubes NaYF4, sodium yttrium fluoride Nc, naphthalocyanine NIPAAm-co-AAm, N-isopropylacrylamide-co-acrylamide NIR, near-infrared NP, nanoparticle OCT, optical coherence tomography ORMOSIL, organically modified silica PA, photoacoustic PAH, poly(allylamine hydrochloride) Pan, panitumumab Pc4, phthalocyanine 4 PCI, photochemical internalization PDD, photodynamic diagnosis pDNA, plasmid DNA PDT, photodynamic therapy PEG, polyethylene glycol PEI, poly(ethylene imine) PET, positron emission tomography Pheo, pheophorbide PHPP, 2,7,12,18-tetramethyl-3,8-di-(1-propoxyethyl)-13,17-bis-(3-hydroxypropyl) porphyrin PI, propidium iodide PIC, photoimmunoconjugate PICEL, photoimmunoconjugate encapsulating liposome PLGA, poly-L-co-glycolic-acid PS, photosensitizer PSiNPs, phosphonate-terminated silica nanoparticles PSS, poly(styrene sulfonate) PT, photothermal PTT, photothermal therapy PTX, paclitaxel pz, porphyrazine QD, quantum dots rGel, gelonin toxin RA, rheumatoid arthritis ROS, reactive oxygen species SDS, sodium dodecyl sulfate SDT, sonodynamic therapy SiNcBOA, silicon naphthalocyanine bisoleate SiO2, silica siRNA, small interfering RNA SLN, solid lipid nanoparticles S. aureus, Staphylococcus aureus SWNTS, single wall carbon nanotubes TEOS, tetraEthOxy silane Tf-Lip, transferring-conjugated liposomes THPMP, tri-hydroxyl silyl propyl methyl phosphonate TPC, 5-(4-carboxyphenyl)-10,15,20-triphenyl-2,3-dihydroxychlorin TPPS2A, disulfonated meso-tetraphenylporphine Tra, trastuzumab UV, ultraviolet VIS, visible light Yb3+, ytterbium ZnPC, zinc phthalocyanine |
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